Journal
ADVANCED SCIENCE
Volume 8, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/advs.202004128
Keywords
atherosclerotic plaques; photodynamics; platelet‐ mimicking systems; radionuclide imaging
Categories
Funding
- National Natural Science Foundation of China [NSFC 81727804, 91859204, 81801816, 81729002, 81771900]
- Natural Science Foundation of Jiangsu Province [SBK2018041202]
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Atherosclerotic plaque is the primary cause of cardiovascular disorders, and traditional clinical strategies are often limited. Researchers have designed a biomimic photodynamic therapeutic system that can target foam cells in early atherosclerotic plaques using platelet membrane-coated upconversion nanoparticle cores loaded with photosensitizer, which shows promising results in alleviating plaque progression.
Atherosclerotic plaque is the primary cause of cardiovascular disorders and remains a therapeutic hurdle for the early intervention of atherosclerosis. Traditional clinical strategies are often limited by surgery-related complications or unsatisfactory effects of long-term drug administration. Inspired by the plaque-binding ability of platelets, a biomimic photodynamic therapeutic system is designed to mitigate the progression of atherosclerotic plaques. This system is composed of photosensitizer-loaded upconversion nanoparticle cores entrapped in the platelet membrane. The platelet membrane coating facilitates specific targeting of the therapeutic system to macrophage-derived foam cells, the hallmark, and main component of early stage atherosclerotic plaques, which is firmly confirmed by in vivo fluorescent and single-photon emission computed tomography/computed tomography (SPECT/CT) radionuclide imaging. Importantly, in vivo phototherapy guided by SPECT/CT imaging alleviates plaque progression. Further immunofluorescence analysis reveals foam cell apoptosis and ameliorated inflammation. This biomimic system, which combines plaque-binding with radionuclide imaging guidance, is a novel, noninvasive, and potent strategy to mitigate the progression of atherosclerotic plaque.
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