Journal
ADVANCED SCIENCE
Volume 8, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/advs.202004014
Keywords
antibacterial; antiviral; drug delivery; oral cancer; tissue regeneration
Categories
Funding
- Italian Ministry of University and Research [PON CCI 2014IT16M2OP005]
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The oral cavity and oropharynx are complex environments susceptible to various insults. Conventional treatments may be compromised by factors like constant salivary flow. The synthesis of nanoparticle-containing agents represents a new and efficient way to deliver drugs to affected tissues in dentistry and oral medicine.
The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.
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