Journal
JOURNAL OF IMMUNOLOGY RESEARCH
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/8835919
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Funding
- National Natural Science Foundation [31402241]
- Basic Public Welfare Research Projects in Zhejiang Province [LGN18C180003]
- National Rabbit Industry Project of China [nycytx-44-3-2]
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The study demonstrated that Rg1 plus oil significantly enhanced the immune effect of rabbit B. bronchiseptica vaccine by increasing IL-2 and IL-4 levels, as well as regulating TLR2 expression. This suggests that Rg1 plus oil could potentially be used as a vaccine adjuvant for B. bronchiseptica vaccine.
Bordetella bronchiseptica (B. bronchiseptica) is an obligately aerobic, oxidase- and catalase-positive, nonfermentative Gram-negative coccobacillus. This study is aimed at examining the immune effects of Rg1, Rg1 plus oil, and other common adjuvants on inactivated B. bronchiseptica vaccine in rabbits. The mechanism underlying the adjuvant effect of Rg1 plus oil on the vaccine was also explored. Rg1 (100 mu g) plus oil significantly improved the immune effect of B. bronchiseptica vaccine at both the humoral and cellular levels. Rg1-oil adjuvant increased the levels of IL-2 and IL-4 in rabbits after immunization. Rg1 (100 mu g) plus oil also significantly increased TLR2 expression and downregulated NF-kappa B in splenocytes. Rg1-oil adjuvant may increase the levels of IL-2 and IL-4 via upregulating TLR2, thereby enhancing the immune effect of B. bronchiseptica vaccine. In conclusion, Rg1 plus oil could be used as a potential vaccine adjuvant for rabbit B. bronchiseptica vaccine.
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