4.4 Article

Gender-related differences in frontal-parietal modular segregation and altered effective connectivity in internet gaming disorder

Journal

JOURNAL OF BEHAVIORAL ADDICTIONS
Volume 10, Issue 1, Pages 123-134

Publisher

AKADEMIAI KIADO ZRT
DOI: 10.1556/2006.2021.00015

Keywords

internet gaming disorder; sex difference; frontal-parietal network; participation coefficient; dynamic causal modeling

Categories

Funding

  1. Cultivation Project of Province-levelled Preponderant Characteristic Discipline of Hangzhou Normal University [20JYXK008]
  2. Zhejiang Provincial Natural Science Foundation [LY20C090005]

Ask authors/readers for more resources

The study revealed abnormalities in modular segregation of the FPN and connections between FPN and CON in male IGD patients, suggesting mechanisms for male vulnerability to IGD. Additionally, increased bottom-up effect from CON to FPN in male IGD subjects could reflect dysfunction between brain networks. Different mechanisms may underlie IGD in males and females, implying that different interventions may be optimal.
Background: Although previous studies have revealed gender-related differences in executive function in internet gaming disorder (IGD), neural mechanisms underlying these processes remain unclear, especially in terms of brain networks. Methods: Resting-state fMRI data were collected from 78 subjects with IGD (39 males, 20.8 +/- 2.16 years old) and 72 with recreational game use (RGU) (39 males, 21.5 +/- 2.56 years old). By utilizing graph theory, we calculated participation coefficients among brain network modules for all participants and analyzed the diagnostic-group-by-gender interactions. We further explored possible causal relationships between networks through spectral dynamic causal modeling (spDCM) to assess differences in between-network connections. Results: Compared to males with RGU, males with IGD demonstrated reduced modular segregation of the frontal-parietal network (FPN). Male IGD subjects also showed increased connections between the FPN and cingulo-opercular network (CON); however, these differences were not found in female subjects. Further spDCM analysis indicated that the causal influence from CON to FPN in male IGD subjects was enhanced relative to that of RGU males, while this influence was relatively reduced in females with IGD. Conclusions: These results suggest poor modular segmentation of the FPN and abnormal FPN/CON connections in males with IGD, suggesting a mechanism for male vulnerability to IGD. An increased bottom-up effect from the CON to FPN in male IGD subjects could reflect dysfunction between the brain networks. Different mechanisms may underlie in IGD, suggesting that different interventions may be optimal in males and females with IGD.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available