Poincare Plot Area of Gamma-Band EEG as a Measure of Emergence From Inhalational General Anesthesia

The Poincare plot obtained from electroencephalography (EEG) has been used to evaluate the depth of anesthesia. A standalone EEG Analyzer application was developed; raw EEG signals obtained from a bispectral index (BIS) monitor were analyzed using an on-line monitoring system. Correlations between Poincare plot parameters and other measurements associated with anesthesia depth were evaluated during emergence from inhalational general anesthesia. Of the participants, 20 were adults anesthetized with sevoflurane (adult(_SEV)), 20 were adults anesthetized with desflurane (adult(_DES)), and 20 were pediatric patients anesthetized with sevoflurane (ped(_SEV)). EEG signals were preprocessed through six bandpass digital filters (f0: 0.5-47 Hz, f1: 0.5-8 Hz, f2: 8-13 Hz, f3: 13-20 Hz, f4: 20-30 Hz, and f5: 30-47 Hz). The Poincare plot-area ratio (PPAR = PPA_fx/PPA_f0, fx = f1 similar to f5) was analyzed at five frequency ranges. Regardless of the inhalational anesthetic used, there were strong linear correlations between the logarithm of PPAR at f5 and BIS (R-2 = 0.67, 0.79, and 0.71, in the adult(_SEV), adult(_DES), and ped(_SEV) groups, respectively). As an additional observation, a part of EMG activity at the gamma range of 30-47 Hz probably influenced the calculations of BIS and PPAR_f5 with a non-negligible level. The logarithm of PPAR in the gamma band was most sensitive to state changes during the emergence process and could provide a new non-proprietary parameter that correlates with changes in BIS during measurement of anesthesia depth.

Automated summary

The Poincare plot obtained from EEG was used to evaluate anesthesia depth, showing strong linear correlations between PPAR at different frequency ranges and BIS measurements. The gamma band activity at 30-47 Hz was found to have the most sensitivity to state changes during anesthesia emergence, potentially offering a new parameter to correlate with changes in BIS.