Journal
FRONTIERS IN PHYSIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.621132
Keywords
inflammatory bowel disease; autophagy; inflammasome; apoptosis; mutation
Categories
Funding
- General Hospital of the Chinese People's Liberation Army [2018ZD-006, 2018MS-012]
- Project of Military Health and Disease Prevention and Control [13BJYZ26]
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IBD, including UC and CD, is an idiopathic intestinal inflammatory disease, where autophagy plays a vital role. Understanding the regulation of autophagy in IBD is crucial for developing novel therapeutic strategies.
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease, including ulcerative colitis (UC) and Crohn's disease (CD). The abnormality of inflammatory and immune responses in the intestine contributes to the pathogenesis and progression of IBD. Autophagy is a vital catabolic process in cells. Recent studies report that autophagy is highly involved in various kinds of diseases, especially inflammation-related diseases, such as IBD. In this review, the biological characteristics of autophagy and its role in IBD will be described and discussed based on recent literature. In addition, several therapies for IBD through modulating the inflammasome and intestinal microbiota taking advantage of autophagy regulation will be introduced. We aim to bring new insight in the exploration of mechanisms for IBD and development of novel therapeutic strategies against IBD.
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