Journal
FRONTIERS IN PHARMACOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2020.596099
Keywords
temporomandibular joint; pain management; intra-TMJ injection; mandibular dysfunction; temporomandibular joint disorder
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Funding
- Natural Science Foundation of China [81970956, 81900806]
- Zhejiang Qianjiang Talent Project [QJD1902024]
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This study summarized commonly used therapeutic agents and novel bioactive molecules in the management of TMD, as well as discussed emerging therapy strategies, strengthening our understanding of pharmacological approaches for TMD therapy.
Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.
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