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Regulation and Physiological Functions of G12/13-Mediated Signaling Pathways
Nobuchika Suzuki et al.
NEUROSIGNALS (2009)
Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation
Lei Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Regulation of amygdalar PKA by β-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning
Yuting Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands
Christopher N Davis et al.
BMC Pharmacology & Toxicology (2009)
Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia
Anantha Shekhar et al.
AMERICAN JOURNAL OF PSYCHIATRY (2008)
Pathways of acetylcholine synthesis, transport and release as targets for treatment of adult-onset cognitive dysfunction
F. Amenta et al.
CURRENT MEDICINAL CHEMISTRY (2008)
PLC-beta 1 knockout mice as a model of disrupted cortical development and plasticity: Behavioral endophenotypes and dysregulation of RGS4 gene expression
Caitlin E. McOmish et al.
HIPPOCAMPUS (2008)
2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists
Gemma N. Ferguson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
G Protein Coupling and Signaling Pathway Activation by M1 Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists
Rachel L. Thomas et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins
Cindy Reiner et al.
LIFE SCIENCES (2008)
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
Rene O. Sanchez-Mejia et al.
NATURE NEUROSCIENCE (2008)
On the analysis of ligand-directed signaling at G protein-coupled receptors
Frederick J. Ehlert
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2008)
Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning
Jennifer J. Brightwell et al.
NEUROBIOLOGY OF LEARNING AND MEMORY (2008)
Muscarinic acetylcholine receptors as CNS drug targets
Christopher J. Langmead et al.
PHARMACOLOGY & THERAPEUTICS (2008)
Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia
W. Y. Chan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration
C. E. McOmish et al.
MOLECULAR PSYCHIATRY (2008)
Current therapeutic options for Alzheimer's disease
Alberto Lleo
CURRENT GENOMICS (2007)
Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory
Yasushi Satoh et al.
JOURNAL OF NEUROSCIENCE (2007)
Disrupted muscarinic M1 receptor signaling correlates with loss of protein kinase C activity and glutamatergic deficit in Alzheimer's disease
Shirley W. Y. Tsang et al.
NEUROBIOLOGY OF AGING (2007)
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology
Katie Leach et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
Towards a muscarinic hypothesis of schizophrenia
T. J. Raedler et al.
MOLECULAR PSYCHIATRY (2007)
Alternative splicing of RGS8 gene changes the binding property to the M1 muscarinic receptor to confer receptor type-specific Gq regulation
Masayuki Itoh et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific cAMP response element-binding protein-deficient mice
C Pittenger et al.
JOURNAL OF NEUROSCIENCE (2006)
Activation of muscarinic M4 receptor augments NGF-induced pro-survival Akt signaling in PC12 cells
EH Wu et al.
CELLULAR SIGNALLING (2006)
Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model
A Degroot et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Subtyping schizophrenia: implications for genetic research
A. Jablensky
MOLECULAR PSYCHIATRY (2006)
DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
JK Millar et al.
SCIENCE (2005)
Allosteric modulation of the cannabinoid CB1 receptor
MR Price et al.
MOLECULAR PHARMACOLOGY (2005)
Roles of phosphorylation-dependent and -independent mechanisms in the regulation of M1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 in hippocampal neurons
JM Willets et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
RJ Griffin et al.
JOURNAL OF NEUROCHEMISTRY (2005)
An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteins
R Mistry et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia
ES Emamian et al.
NATURE GENETICS (2004)
RGS2 binds directly and selectively to the M1 muscarinic acetylcholine receptor third intracellular loop to modulate Gq/11α signaling
LS Bernstein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor
R Mitchell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions
AA Roy et al.
MOLECULAR PHARMACOLOGY (2003)
Role of protein kinase B in Alzheimer's neurofibrillary pathology
JJ Pei et al.
ACTA NEUROPATHOLOGICA (2003)
M-1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease - Implications in future therapy
A Fisher et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2003)
M1 muscarinic receptor signaling in mouse hippocampus and cortex
AC Porter et al.
BRAIN RESEARCH (2002)
G protein-coupled receptor allosterism and complexing
A Christopoulos et al.
PHARMACOLOGICAL REVIEWS (2002)
Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice
DJ Gerber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices
JL Berkeley et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2001)
The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons
SE Hamilton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Rho proteins: Linking signaling with membrane trafficking
AJ Ridley
TRAFFIC (2001)
Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia
K Mirnics et al.
MOLECULAR PSYCHIATRY (2001)
The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins -: Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling
U Rümenapp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)