Journal
FRONTIERS IN NEUROSCIENCE
Volume 15, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.654238
Keywords
impulse control disorders; rodent models; dopamine agonist; non-motor symptoms; Parkinson’ s disease
Categories
Funding
- Rice University's Office of Undergraduate Research and Inquiry
- Rice University's Department of BioSciences
- Office of Research at the Baylor College of Medicine
- Canadian Institutes of Health Research (CIHR) [PJT-162312]
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Parkinson's disease patients are not only affected by motor impairments, but also at risk for impulse control disorders. There is currently a lack of consensus on the best approach to addressing these symptoms.
Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by symptoms that impact both motor and non-motor domains. Outside of motor impairments, PD patients are at risk for impulse control disorders (ICDs), which include excessively disabling impulsive and compulsive behaviors. ICD symptoms in PD (PD + ICD) can be broadly conceptualized as a synergistic interaction between dopamine agonist therapy and the many molecular and circuit-level changes intrinsic to PD. Aside from discontinuing dopamine agonist treatment, there remains a lack of consensus on how to best address ICD symptoms in PD. In this review, we explore recent advances in the molecular and neuroanatomical mechanisms underlying ICD symptoms in PD by summarizing a rapidly accumulating body of clinical and preclinical studies, with a special focus on the utility of rodent models in gaining new insights into the neurochemical basis of PD + ICD. We also discuss the relevance of these findings to the broader problem of impulsive and compulsive behaviors that impact a range of neuropsychiatric syndromes.
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