4.6 Review

Roles of Non-coding RNAs in Central Nervous System Axon Regeneration

Journal

FRONTIERS IN NEUROSCIENCE
Volume 15, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.630633

Keywords

non-coding RNA; nerve regeneration; central nervous system; optic nerve injury; spinal cord injury

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Funding

  1. Natural Science Foundation of Liaoning Province [2019-MS-394]
  2. 345 Talent Project of Shengjing Hospital

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This review summarizes the important roles of non-coding RNAs in axon regeneration after central nervous system injuries, especially lncRNA, miRNA, and circRNA. It also reveals the interactive networks among them.
Axons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to promote the regeneration capability of injured nerves. Evidence has shown that non-coding RNAs play an essential role in nerve regeneration, especially long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). In this review, we profile their separate roles in axon regeneration after CNS injuries, such as spinal cord injury (SCI) and optic nerve injury. In addition, we also reveal the interactive networks among non-coding RNAs.

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