Journal
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
Volume 28, Issue 6, Pages 3367-3373Publisher
ELSEVIER
DOI: 10.1016/j.sjbs.2021.02.085
Keywords
AgNPs; Calotropis procera; Splenocyte; Antimicrobial; Anticancer; Somra (Acacia) honey
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Funding
- Scientific Research Deanship at King Khalid University
- Ministry of Education in KSA [IFP-KKU-2020/5]
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The study revealed that CPLWExt and honey have the ability to produce silver nanoparticles, as well as showing immunomodulatory and antibacterial effects. Mixing Somra honey with CPLWExt demonstrated good immunostimulatory effects, while combining Somra honey with honey showed anticancer effects.
Calotropis procera and Somra (Acacia) honey are used in traditional medicine. The benefits of mixing 20% Somra honey and C. procera leaf water extract (CPLWExt) were aimed to be studied. Honey/CPLWExt were utilized to produce silver nanoparticles (AgNPs) separately. AgNPs were characterized via UV/Vis and electron microscope scanning. Bio-molecules in CPLWExt/honey were investigated utilizing FT-IR spectroscopy. Biological activities of CPLWExt and honey were tested. The outcomes showed that CPLWExt and honey have numerous functional groups and could produce AgNPs. CPLWExt, CPLWExt + AgNPs, honey and honey + AgNPs hindered the growth of rat splenocytes, while CPLWExt + honey invigorated it. Antimicrobial power was found in CPLWExt and honey, which increased in the presence of AgNPs. Honey/honey + AgNPs suppressed the proliferation of HeLa and HepG2 cells. In conclusion, honey/CPLWExt could produce AgNPs and showed immunomodulatory and antibacterial power. Somra honey/honey + AgNPs have anticancer power. Somra honey + CPLWExt reflected a good immunostimulatory powers that can be nominated as an immunostimulant. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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