Outer Membrane Vesicles of Gram-Negative Bacteria: An Outlook on Biogenesis

Outer membrane vesicles (OMVs) from Gram-negative bacteria were first described more than 50 years ago. However, the molecular mechanisms involved in biogenesis began to be studied only in the last few decades. Presently, the biogenesis and molecular mechanisms for their release are not completely known. This review covers the most recent information on cellular components involved in OMV biogenesis, such as lipoproteins and outer membrane proteins, lipopolysaccharide, phospholipids, quorum-sensing molecules, and flagella.

Automated summary

OMVs from Gram-negative bacteria were first described over 50 years ago, but the molecular mechanisms involved in their biogenesis have only been studied in recent decades. The current knowledge of OMV biogenesis and release mechanisms is incomplete, with recent studies focusing on various cellular components.