Journal
FRONTIERS IN MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.638094
Keywords
antimicrobial resistance; nosocomial infections; phage library; phage therapy; disinfection
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Funding
- National Major Science and Technology Projects of China [2020ZX09201001-005-003]
- Natural Science Foundation of Shanghai [20Y11900300]
- National Natural Science Foundation of China [82070772]
- Clinical Research Plan of SHDC [SHDC2020CR2028B]
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Nosocomial infections are a significant healthcare burden globally, exacerbated by antimicrobial resistance. Utilizing bacteriophages from an expanding library offers a promising alternative for tackling AMR bacteria and provides a database for monitoring and treatment of hospital-acquired infections.
Nosocomial infections (NIs) are hospital-acquired infections which pose a high healthcare burden worldwide. The impact of NIs is further aggravated by the global spread of antimicrobial resistance (AMR). Conventional treatment and disinfection agents are often insufficient to catch up with the increasing AMR and tolerance of the pathogenic bacteria. This has resulted in a need for alternative approaches and raised new interest in therapeutic bacteriophages (phages). In contrast to the limited clinical options available against AMR bacteria, the extreme abundance and biodiversity of phages in nature provides an opportunity to establish an ever-expanding phage library that collectively provides sustained broad-spectrum and poly microbial coverage. Given the specificity of phage-host interactions, phage susceptibility testing can serve as a rapid and cost-effective method for bacterial subtyping. The library can also provide a database for routine monitoring of nosocomial infections as a prelude to preparing ready-to-use phages for patient treatment and environmental sterilization. Despite the remaining obstacles for clinical application of phages, the establishment of phage libraries, pre-stocked phage vials prepared to good manufacturing practice (GMP) standards, and pre-optimized phage screening technology will facilitate efforts to make phages available as modern medicine. This may provide the breakthrough needed to demonstrate the great potential in nosocomial infection management.
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