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AMERICAN JOURNAL OF PATHOLOGY (2014)
Free Fatty Acid (FFA) and Hydroxy Carboxylic Acid (HCA) Receptors
Stefan Offermanns
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 54 (2014)
Cell Surface Lactate Receptor GPR81 Is Crucial for Cancer Cell Survival
Christina L. Roland et al.
CANCER RESEARCH (2014)
Regulation of pyruvate metabolism and human disease
Lawrence R. Gray et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2014)
Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism
Knut H. Lauritzen et al.
CEREBRAL CORTEX (2014)
Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing
Taku Sakurai et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor- and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity
Rafaz Hoque et al.
GASTROENTEROLOGY (2014)
Upregulation of CD147 protects hepatocellular carcinoma cell from apoptosis through glycolytic switch via HIF-1 and MCT-4 under hypoxia
Xia Ke et al.
HEPATOLOGY INTERNATIONAL (2014)
Glucose pathways adaptation supports acquisition of activated microglia phenotype
J. Gimeno-Bayon et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2014)
Distinct Pathways of ERK1/2 Activation by Hydroxy-Carboxylic Acid Receptor-1
Guo Li et al.
PLOS ONE (2014)
Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients
Courtney A. Crane et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The formation of the granuloma in tuberculosis infection
Ian M. Orme et al.
SEMINARS IN IMMUNOLOGY (2014)
A new unifying theory of the pathogenesis of tuberculosis
Ian M. Orme
TUBERCULOSIS (2014)
Interaction of Mycobacterium tuberculosis with Host Cell Death Pathways
Lalitha Srinivasan et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2014)
Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules
David F. Ackart et al.
PATHOGENS AND DISEASE (2014)
The mitochondrial L-lactate dehydrogenase affair
Salvatore Passarella et al.
FRONTIERS IN NEUROSCIENCE (2014)
Breaking the vicious cycle between breast cancer cells and tumor-associated macrophages
Shicheng Su et al.
ONCOIMMUNOLOGY (2014)
Lactate oxidation in human skeletal muscle mitochondria
Robert A. Jacobs et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
The Warburg effect then and now: From cancer to inflammatory diseases
Eva M. Palsson-McDermott et al.
BIOESSAYS (2013)
The Relationship between Tumor Blood Flow, Angiogenesis, Tumor Hypoxia, and Aerobic Glycolysis
Leif Ostergaard et al.
CANCER RESEARCH (2013)
CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells
Denise K. Walters et al.
CELL CYCLE (2013)
Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer
Joseph M. Curry et al.
CELL CYCLE (2013)
Lactate Dehydrogenase A in Cancer: A Promising Target for Diagnosis and Therapy
Ping Miao et al.
IUBMB LIFE (2013)
Intracellular Mycobacterium tuberculosis Exploits Host-derived Fatty Acids to Limit Metabolic Stress
Wonsik Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Targeting lactate metabolism for cancer therapeutics
Joanne R. Doherty et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells
Zaheed Husain et al.
JOURNAL OF IMMUNOLOGY (2013)
Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
Stephen Yiu Chuen Choi et al.
JOURNAL OF PATHOLOGY (2013)
Enzymes involved in L-lactate metabolism in humans
M. Adeva et al.
MITOCHONDRION (2013)
Metabolic symbiosis in cancer: Refocusing the Warburg lens
Erica C. Nakajima et al.
MOLECULAR CARCINOGENESIS (2013)
Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control efforts
Ben J. Marais et al.
LANCET INFECTIOUS DISEASES (2013)
Advances in the development of new tuberculosis drugs and treatment regimens
Alimuddin Zumla et al.
NATURE REVIEWS DRUG DISCOVERY (2013)
Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer
Kelly M. Kennedy et al.
PLOS ONE (2013)
Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway
Luigi Bozzo et al.
PLOS ONE (2013)
Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
Carlos Carmona-Fontaine et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Optimization of Tumor Radiotherapy With Modulators of Cell Metabolism: Toward Clinical Applications
Pierre Danhier et al.
SEMINARS IN RADIATION ONCOLOGY (2013)
Targeting cellular metabolism to improve cancer therapeutics
Y. Zhao et al.
CELL DEATH & DISEASE (2013)
Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism
Philip M. Elks et al.
PLOS PATHOGENS (2013)
Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice
Paolo E. Porporato et al.
ANGIOGENESIS (2012)
A Mathematical Model for the Glucose-Lactate Metabolism of in Vitro Cancer Cells
Berta Mendoza-Juez et al.
BULLETIN OF MATHEMATICAL BIOLOGY (2012)
Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay
Tania Fiaschi et al.
CANCER RESEARCH (2012)
Hypoxia upregulates CD147 through a combined effect of HIF-1 and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors
Xia Ke et al.
CARCINOGENESIS (2012)
Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype
Varshneya Singh et al.
CELL HOST & MICROBE (2012)
The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type
Mariia O. Yuneva et al.
CELL METABOLISM (2012)
Protection versus pathology in tuberculosis: recent insights
Andrea M. Cooper et al.
CURRENT OPINION IN IMMUNOLOGY (2012)
Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment
Yanique L. Rattigan et al.
EXPERIMENTAL CELL RESEARCH (2012)
The monocarboxylate transporter familyuStructure and functional characterization
Andrew P. Halestrap
IUBMB LIFE (2012)
Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions
Jamie Harper et al.
JOURNAL OF INFECTIOUS DISEASES (2012)
Metabolomic Signatures in Guinea Pigs Infected with Epidemic-Associated W-Beijing Strains of Mycobacterium tuberculosis
Bagganahalli S. Somashekar et al.
JOURNAL OF PROTEOME RESEARCH (2012)
Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
Pierre Sonveaux et al.
PLOS ONE (2012)
Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects
Curt A. Dvorak et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
3,5-Dihydroxybenzoic Acid, a Specific Agonist for Hydroxycarboxylic Acid 1, Inhibits Lipolysis in Adipocytes
Changlu Liu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4
Saskia E. Rademakers et al.
BMC CANCER (2011)
Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise
Kieron Rooney et al.
BRITISH JOURNAL OF NUTRITION (2011)
Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
Frederique Vegran et al.
CANCER RESEARCH (2011)
Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells
Hiroto Izumi et al.
CANCER SCIENCE (2011)
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
Eric V. Dang et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Evidence for a stromal-epithelial lactate shuttle in human tumors MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
Diana Whitaker-Menezes et al.
CELL CYCLE (2011)
Inflammation inhibits GPR81 expression in adipose tissue
Kenneth R. Feingold et al.
INFLAMMATION RESEARCH (2011)
Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
Kristina Goetze et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Metabolic Profiling of Lung Granuloma in Mycobacterium tuberculosis Infected Guinea Pigs: Ex vivo 1H Magic Angle Spinning NMR Studies
B. S. Somashekar et al.
JOURNAL OF PROTEOME RESEARCH (2011)
Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography
Q. L. Zhao et al.
LASER PHYSICS LETTERS (2011)
Location of Intra- and Extracellular M. tuberculosis Populations in Lungs of Mice and Guinea Pigs during Disease Progression and after Drug Treatment
Donald R. Hoff et al.
PLOS ONE (2011)
Mycobacterium tuberculosis Induces an Atypical Cell Death Mode to Escape from Infected Macrophages
Jinhee Lee et al.
PLOS ONE (2011)
T Cells from Programmed Death-1 Deficient Mice Respond Poorly to Mycobacterium tuberculosis Infection
Sultan Tousif et al.
PLOS ONE (2011)
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
Renaud Le Floch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The role of the microenvironment in tumor growth and invasion
Yangjin Kim et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
Study of GPR81, the Lactate Receptor, from Distant Species Identifies Residues and Motifs Critical for GPR81 Functions
Chester Kuei et al.
MOLECULAR PHARMACOLOGY (2011)
An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81
Kashan Ahmed et al.
CELL METABOLISM (2010)
L-lactate metabolism can occur in normal and cancer prostate cells via the novel mitochondrial L-lactate dehydrogenase
Lidia De Bari et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2010)
Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes
Katrin Dietl et al.
JOURNAL OF IMMUNOLOGY (2010)
The Mycobacterium bovis Bacille Calmette-Guerin Phagosome Proteome
Bai-Yu Lee et al.
MOLECULAR & CELLULAR PROTEOMICS (2010)
Granuloma Encapsulation Is a Key Factor for Containing Tuberculosis Infection in Minipigs
Olga Gil et al.
PLOS ONE (2010)
Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens
Nadine Werth et al.
PLOS ONE (2010)
Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis
Eszter Lazar-Molnar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
Anne Le et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
UTILITY OF SERUM LDH ISOFORMS IN THE ASSESSMENT OF MYCOBACTERIUM TUBERCULOSIS INDUCED PATHOLOGY IN TB PATIENTS OF SAHARIYA TRIBE
P. R. Sharma et al.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2010)
Who Benefits from Granulomas, Mycobacteria or Host?
Tyler D. Bold et al.
CELL (2009)
HIF-1α induces MXI1 by alternate promoter usage in human neuroblastoma cells
Tobias Lofstedt et al.
EXPERIMENTAL CELL RESEARCH (2009)
Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81
Changlu Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Peroxisome Proliferator-activated Receptor γ Regulates Expression of the Anti-lipolytic G-protein-coupled Receptor 81 (GPR81/Gpr81)
Ellen H. Jeninga et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cell-cell and intracellular lactate shuttles
George A. Brooks
JOURNAL OF PHYSIOLOGY-LONDON (2009)
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
Han Xie et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Lactate dehydrogenase-5 (LDH-5) expression in human gastric cancer:: Association with hypoxia-inducible factor (HIF-1α) pathway, angiogenic factors production and poor prognosis
Yanislav Kolev et al.
ANNALS OF SURGICAL ONCOLOGY (2008)
Role of GPR81 in lactate-mediated reduction of adipose lipolysis
Tian-Quan Cai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer
S. M. Wigfield et al.
BRITISH JOURNAL OF CANCER (2008)
Mycobacterium tuberculosis prevents inflammasome activation
Sharon S. Master et al.
CELL HOST & MICROBE (2008)
Mitochondria and L-lactate metabolism
Salvatore Passarella et al.
FEBS LETTERS (2008)
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
Laura E. Via et al.
INFECTION AND IMMUNITY (2008)
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
Pierre Sonveaux et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis
Javier O. Jurado et al.
JOURNAL OF IMMUNOLOGY (2008)
Mitochondrial Lactate Dehydrogenase Is Involved in Oxidative-Energy Metabolism in Human Astrocytoma Cells (CCF-STTG1)
Joseph Lemire et al.
PLOS ONE (2008)
Glia: the fulcrum of brain diseases
C. Giaume et al.
CELL DEATH AND DIFFERENTIATION (2007)
Differential drug susceptibility of intracellular and extracellular tuberculosis, and the impact of P-glycoprotein
Ruben C. Hartkoorn et al.
TUBERCULOSIS (2007)
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Karin Fischer et al.
BLOOD (2007)
HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
Ryo Fukuda et al.
CELL (2007)
A caspase-independent pathway mediates macrophage cell death in response to Mycobacterium tuberculosis infection
Mary P. O'Sullivan et al.
INFECTION AND IMMUNITY (2007)
Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1α C-terminal activation domain
Stefan Kaluz et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
MS Ullah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Monocarboxylate transporter MCT1 is a target for immunosuppression
CM Murray et al.
NATURE CHEMICAL BIOLOGY (2005)
Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)
AE Greijer et al.
JOURNAL OF PATHOLOGY (2005)
Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer
MI Koukourakis et al.
CLINICAL & EXPERIMENTAL METASTASIS (2005)
Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice
PC Karakousis et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Lactate: Mirror and motor of tumor malignancy
S Walenta et al.
SEMINARS IN RADIATION ONCOLOGY (2004)
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: An in vitro study
SP Mathupala et al.
NEUROSURGERY (2004)
Lactate metabolism: a new paradigm for the third millennium
LB Gladden
JOURNAL OF PHYSIOLOGY-LONDON (2004)
Partial reconstruction of in vitro gluconeogenesis arising from mitochondrial L-lactate uptake/metabolism and oxaloacetate export via novel L-lactate translocators
L de Bari et al.
BIOCHEMICAL JOURNAL (2004)
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program
MI Voskuil et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis
MI Koukourakis et al.
BRITISH JOURNAL OF CANCER (2003)
Immunopathogenesis of pulmonary granulomas in the guinea pig after infection with Mycobacterium tuberculosis
OC Turner et al.
INFECTION AND IMMUNITY (2003)
Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing
O Trabold et al.
WOUND REPAIR AND REGENERATION (2003)
Discovery and mapping of ten novel G protein-coupled receptor genes
DK Lee et al.
GENE (2001)
HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing
M Ivan et al.
SCIENCE (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
P Kirk et al.
EMBO JOURNAL (2000)
Expression of the lactate transporter MCT1 in macrophages
EL Hahn et al.
SHOCK (2000)