Synthesis of β-Alkoxy Amines from Alkenes, Sulfonyl Azides, and Alcohols though Copper-Catalyzed Three-Component Tandem Reactions via Regioselective Ring-Opening of Aziridine Intermediates

A copper-catalyzed three-component tandem reaction of alkenes, sulfonyl azides, and alcohols is described. This straightforward transformation provides a practical method for the synthesis of valuable beta-alkoxy amines from easily accessible starting materials under comparative cheap copper catalysis without external ligands though regioselective ring-opening reaction of aziridine intermediates. This reaction has a broad functional groups tolerance and the yields are generally good.

Automated summary

A copper-catalyzed three-component tandem reaction involving alkenes, sulfonyl azides, and alcohols has been described for the synthesis of valuable beta-alkoxy amines. This method is practical and cost-effective, showing good yields and tolerance towards various functional groups.