4.5 Article

Molybdenum-Catalyzed Deoxygenative Cyclization of Carbonyl Compounds for the Synthesis of Pyrido[2,1-a]isoindoles

Journal

ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 4, Pages 753-756

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202100038

Keywords

carbonyl compounds; deoxygenation; molybdenum; pyridoisoindoles; quinones

Funding

  1. MEXT [18H03911, 17K19122, 19K15565]
  2. Mitsubishi Tanabe Pharma Award in Synthetic Organic Chemistry, Japan
  3. Grants-in-Aid for Scientific Research [17K19122, 19K15565] Funding Source: KAKEN

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A simple catalytic system composed of Mo(0) and ortho-quinone as catalyst, and phosphine as a reductant, has been developed for the synthesis of pyridoisoindoles and pyridoisoindolium salts through deoxygenation of carbonyl compounds.
A simple catalytic system consisting of Mo(0) and ortho-quinone as catalyst and phosphine as a reductant has been developed for the synthesis of pyridoisoindoles and pyridoisoindolium salts through the deoxygenation of carbonyl compounds.

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