Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 10, Issue 6, Pages 1382-1385Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202000635
Keywords
difunctionalization of arene; oxime ester; multisubstituted indole; copper
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Funding
- Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province [CSPC01907]
- Education Department of Sichuan Province [18ZA0341]
- Vanadium and Tiatanium Resource Comprehensive Utilization Key Laboratory of Sichuan Province [2020FTSZ09]
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A copper-catalyzed cascade synthesis of substituted 2-aryl-1H-indoles from phenols and oximes is developed, involving dual C-H bond cleavage of phenols and cyclization with oximes. The reaction proceeds smoothly under mild conditions without any additives.
A copper-catalyzed cascade synthesis of substituted 2-aryl-1H-indoles from phenols and oximes is developed. This reaction involves dual C-H bond cleavage of phenols and cyclization with oximes and proceeds smoothly under mild conditions without any additives.
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