Journal
STEM CELLS TRANSLATIONAL MEDICINE
Volume 10, Issue 5, Pages 681-693Publisher
OXFORD UNIV PRESS
DOI: 10.1002/sctm.20-0361
Keywords
adult stem cells; disease modeling; neural crest stem cells; placental stem cells; regenerative medicine
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Funding
- National Natural Science Foundation of China [32000968]
- UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Innovation Award
- National Institutes of Health [R56DE029157, HL121450]
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Neural crest stem cells (NCSCs) and neural crest-like stem cells (NCLSCs) are transient populations with self-renewal and multipotency properties, which can be derived through various methods and hold great potential for tissue regeneration applications.
Neural crest stem cells (NCSCs) are a transient population of cells that arise during early vertebrate development and harbor stem cell properties, such as self-renewal and multipotency. These cells form at the interface of non-neuronal ectoderm and neural tube and undergo extensive migration whereupon they contribute to a diverse array of cell and tissue derivatives, ranging from craniofacial tissues to cells of the peripheral nervous system. Neural crest-like stem cells (NCLSCs) can be derived from pluripotent stem cells, placental tissues, adult tissues, and somatic cell reprogramming. NCLSCs have a differentiation capability similar to NCSCs, and possess great potential for regenerative medicine applications. In this review, we present recent developments on the various approaches to derive NCLSCs and the therapeutic application of these cells for tissue regeneration.
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