Journal
PLOS PATHOGENS
Volume 17, Issue 2, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1009253
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Funding
- MOE [R-571-000-037-114, R-571-000061-114]
- Chinese Scholarship Council (CSC) scholarship
- Chengdu Giant Panda Breeding Research Foundation [CPF2017-12]
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Blastocystis plays a significant role in the human gut microbiota, with studies indicating it has correlations with other microbial communities and contributes to maintaining host immunological homeostasis. While recent research suggests Blastocystis may reduce beneficial bacteria, most reports indicate it is a common component of a healthy gut microbiome.
The human gut microbiota is a diverse and complex ecosystem that is involved in beneficial physiological functions as well as disease pathogenesis. Blastocystis is a common protistan parasite and is increasingly recognized as an important component of the gut microbiota. The correlations between Blastocystis and other communities of intestinal microbiota have been investigated, and, to a lesser extent, the role of this parasite in maintaining the host immunological homeostasis. Despite recent studies suggesting that Blastocystis decreases the abundance of beneficial bacteria, most reports indicate that Blastocystis is a common component of the healthy gut microbiome. This review covers recent finding on the potential interactions between Blastocystis and the gut microbiota communities and its roles in regulating host immune responses.
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