Related references
Note: Only part of the references are listed.BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers
Florence Coussy et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platform
Thomas Gonatopoulos-Pournatzis et al.
NATURE BIOTECHNOLOGY (2020)
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
Steven M. Corsello et al.
NATURE CANCER (2020)
One hundred years of Drosophila cancer research: no longer in solitude
Santiago Nahuel Villegas
DISEASE MODELS & MECHANISMS (2019)
Next-generation characterization of the Cancer Cell Line Encyclopedia
Mahmoud Ghandi et al.
NATURE (2019)
A personalized platform identifies trametinib plus zoledronate for a patient with KRAS-mutant metastatic colorectal cancer
Erdem Bangi et al.
SCIENCE ADVANCES (2019)
Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer
Assaf Magen et al.
CELL REPORTS (2019)
Pan-cancer whole-genome analyses of metastatic solid tumours
Peter Priestley et al.
NATURE (2019)
A view on drug resistance in cancer
Neil Vasan et al.
NATURE (2019)
Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
Barbara De Kegel et al.
PLOS GENETICS (2019)
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Xueqian Gong et al.
CANCER DISCOVERY (2019)
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival
Matthew G. Oser et al.
CANCER DISCOVERY (2019)
Molecular Interaction Search Tool (MIST): an integrated resource for mining gene and protein interaction data
Yanhui Hu et al.
NUCLEIC ACIDS RESEARCH (2018)
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega et al.
CELL (2018)
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Marc L. Hyer et al.
NATURE MEDICINE (2018)
Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer
Rachel Brough et al.
ONCOGENE (2018)
Systematic analysis of complex genetic interactions
Elena Kuzmin et al.
SCIENCE (2018)
Harnessing synthetic lethality to predict the response to cancer treatment
Joo Sang Lee et al.
NATURE COMMUNICATIONS (2018)
Synthetic Lethality and Cancer - Penetrance as the Major Barrier
Colm J. Ryan et al.
TRENDS IN CANCER (2018)
The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts
Renier Velez-Cruz et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Transcription elongation factors represent in vivo cancer dependencies in glioblastoma
Tyler E. Miller et al.
NATURE (2017)
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells
Robin M. Meyers et al.
NATURE GENETICS (2017)
Synthetic lethality and cancer
Nigel J. O'Neil et al.
NATURE REVIEWS GENETICS (2017)
PARP inhibitors: Synthetic lethality in the clinic
Christopher J. Lord et al.
SCIENCE (2017)
Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
Sheng Yu Ku et al.
SCIENCE (2017)
Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice
Tomasz Sewastianik et al.
BLOOD ADVANCES (2017)
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles
Aravind Subramanian et al.
CELL (2017)
Defining a Cancer Dependency Map
Aviad Tsherniak et al.
CELL (2017)
Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
Rita Cascao et al.
FRONTIERS IN MEDICINE (2017)
Cytoscape.js: a graph theory library for visualisation and analysis
Max Franz et al.
BIOINFORMATICS (2016)
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
Richard Marcotte et al.
CELL (2016)
A Landscape of Pharmacogenomic Interactions in Cancer
Francesco Iorio et al.
CELL (2016)
RB1: a prototype tumor suppressor and an enigma
Nicholas J. Dyson
GENES & DEVELOPMENT (2016)
RB1 deficiency in triple-negative breast cancer induces rnitochondrial protein translation
Robert A. Jones et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo et al.
SCIENCE (2016)
Cancer Drug Development Using Drosophila as an in vivo Tool: From Bedside to Bench and Back
Amarish Kumar Yadav et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2016)
Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomas
Chencheng Xie et al.
Molecular Cancer (2015)
Rb1 and Pten Co-Deletion in Osteoblast Precursor Cells Causes Rapid Lipoma Formation in Mice
Emma A. Filtz et al.
PLOS ONE (2015)
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Brinton Seashore-Ludlow et al.
CANCER DISCOVERY (2015)
Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining
Rebecca Cook et al.
CELL REPORTS (2015)
Rb Loss Is Characteristic of Prostatic Small Cell Neuroendocrine Carcinoma
Hsueh-Li Tan et al.
CLINICAL CANCER RESEARCH (2014)
The survival gene MED4 explains low penetrance retinoblastoma in patients with large RB1 deletion
Catherine Dehainault et al.
HUMAN MOLECULAR GENETICS (2014)
Identification of Small Molecule Inhibitors of Pre-mRNA Splicing
Andrea Pawellek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization
Brittany D. Wright et al.
NEURON (2014)
Systematic screen of chemotherapeutics in Drosophila stem cell tumors
Michele Markstein et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors
Hongling Zhao et al.
CANCER CELL (2013)
Pharmacological Inactivation of Skp2 SCF Ubiquitin Ligase Restricts Cancer Stem Cell Traits and Cancer Progression
Chia-Hsin Chan et al.
CELL (2013)
Loss of RBF1 changes glutamine catabolism
Brandon N. Nicolay et al.
GENES & DEVELOPMENT (2013)
RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs
Tyler J. W. Robinson et al.
PLOS ONE (2013)
Protein Complex-Based Analysis Framework for High-Throughput Data Sets
Arunachalam Vinayagam et al.
SCIENCE SIGNALING (2013)
FlyPrimerBank: An Online Database for Drosophila melanogaster Gene Expression Analysis and Knockdown Evaluation of RNAi Reagents
Yanhui Hu et al.
G3-GENES GENOMES GENETICS (2013)
Topotecan and Vincristine Combination Is Effective Against Advanced Bilateral Intraocular Retinoblastoma and Has Manageable Toxicity
Ibrahim Qaddoumi et al.
CANCER (2012)
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
Arvin C. Dar et al.
NATURE (2012)
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation
David Nittner et al.
NATURE CELL BIOLOGY (2012)
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
Ethan Cerami et al.
CANCER DISCOVERY (2012)
An integrative approach to ortholog prediction for disease-focused and other functional studies
Yanhui Hu et al.
BMC BIOINFORMATICS (2011)
Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain
Lionel M. L. Chow et al.
CANCER CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Conserved RB functions in development and tumor suppression
Gabriel M. Gordon et al.
PROTEIN & CELL (2011)
Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2
Binghui Li et al.
CANCER CELL (2010)
Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1(+/-) mice
Hongbo Wang et al.
NATURE GENETICS (2010)
Somatic p16INK4a loss accelerates melanomagenesis
K. B. Monahan et al.
ONCOGENE (2010)
Vectors and parameters that enhance the efficacy of RNAi-mediated gene disruption in transgenic Drosophila
Benjamin Haley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Combined Inactivation of pRB and Hippo Pathways Induces Dedifferentiation in the Drosophila Retina
Brandon N. Nicolay et al.
PLOS GENETICS (2010)
Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila
Benoit Biteau et al.
PLOS GENETICS (2010)
RNaiCut: automated detection of significant genes from functional genomic screens
Irene M. Kaplow et al.
NATURE METHODS (2009)
The Biflavonoid Isoginkgetin Is a General Inhibitor of Pre-mRNA Splicing
Kristine O'Brien et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
Yili Yang et al.
CANCER RESEARCH (2007)
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
Sean R. Collins et al.
NATURE (2007)
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
Justin Lamb et al.
SCIENCE (2006)
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
V Khurana et al.
CURRENT BIOLOGY (2006)
The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes
H Xiao et al.
ONCOGENE (2005)
Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model
R Hill et al.
CANCER RESEARCH (2005)
ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma
M Vidal et al.
CANCER RESEARCH (2005)
Systematic interpretation of genetic interactions using protein networks
R Kelley et al.
NATURE BIOTECHNOLOGY (2005)
Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene
KA Edgar et al.
GENETICS (2005)
Osteosarcoma cell lines display variable individual reactions on wildtype P53 and Rb tumour-suppressor transgenes
OJC Hellwinkel et al.
JOURNAL OF GENE MEDICINE (2005)
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase
G Bornstein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2
O Stevaux et al.
EMBO JOURNAL (2002)
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
GH Fisher et al.
GENES & DEVELOPMENT (2001)
Share Paper
