Journal
MOLECULAR BRAIN
Volume 14, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13041-021-00760-3
Keywords
Attention; OBAT; Prefrontal cortex; Dopamine; D1 receptor; D2 receptor; Antagonist; C-Fos
Categories
Funding
- Japan Society for the Promotion of Science [1/H04252, 18K19/61, 20K166/9, 20K07931]
- Private University Research Branding Project from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT)
- Smoking Research Foundation
- Grants-in-Aid for Scientific Research [20K07931] Funding Source: KAKEN
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This study explored the impact of dopamine D1 and D2 receptors in the prefrontal cortex on attention and neuronal activity in various brain regions. Both receptor antagonists induced attentional impairment in a mouse attention test, indicating their association with attention. Neuronal activity analysis revealed selective activation of different brain regions based on receptor types, suggesting distinct roles of dopamine D1 and D2 receptors in attention regulation.
Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice. Disruption of the dopaminergic neuronal system in the PFC induced attentional impairment in the OBAT. However, previous studies have not systematically examined which specific brain regions are associated with the blockade of PFC dopamine D1 and D2-receptors in the OBAT. In this study, we investigated the association of dopamine D1 and D2-receptors in the PFC with attention and neuronal activity in diverse brain regions. We found that both dopamine D1 and D2-receptor antagonists induced attentional impairment in the OBAT by bilateral microinjection into the PFC of mice, suggesting that both dopamine D1 and D2-receptors were associated with attention in the OBAT. Our analysis of the neuronal activity as indicated by c-Fos expression in 11 different brain regions showed that based on the antagonist types, there was selective activation of several brain regions. Overall, this study suggests that both dopamine D1 and D2-receptors play a role in attention through different neuronal circuits in the PFC of mice.
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