Journal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volume 18, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijerph18041549
Keywords
chronic pain; hippocampus; brain; cognitive impairment
Funding
- Spanish Ministry of Education, Culture, and Sport [FPU17/03130]
- regional department of economy and infrastructure of the Government of Extremadura
- European Social Fund [PD16008]
- Spanish Ministry of Education, Culture and Sport [FPU18/05655]
- Spanish Ministry of Sciences and Innovation [PID2019-107191RB-I00/AEI/10.13039/501100011033]
- the Research Grant for Groups - Junta de Extremadura (Regional Government of Extremadura) [GR18155]
- European Regional Development Fund (ERDF/FEDER) a way of doing Europe
- Biomedical Research Networking Center on Frailty and Healthy Aging (CIBERFES)
- FEDER funds from the European Union [CB16/10/00477]
- 4IE+ project - Interreg V-A Espana-Portugal (POCTEP) 2014-2020 program a way of doing Europe [0499_4IE_PLUS_4_E]
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This study found that women with FM have lower volumes of hippocampal subfields compared to healthy women. Regression models revealed that various covariates, such as age, cognitive impairment, or depression, are associated with specific subfields.
Patients with fibromyalgia (FM) show widespread pain associated with other symptoms such as cognitive problems, depression, and anxiety among others associated with alterations in the central nervous system. The hippocampal subfields had differences in function, histology, and connectivity with other brain regions, and are altered in different diseases. This study evaluates the volumetric differences between patients with FM compared with a healthy control group. A total of 49 women with, and 43 healthy women completed this study. T1-weighted MRI was used to assess brain volume, and FreeSurfer software was used to segment the hippocampal subfields. Women with FM had a significant reduction in most of the hippocampal subfields. The regression equation models were obtained to predict the volume of specific subfields of the right and left hippocampus. These findings provide that women with FM have lower hippocampal subfields volumes compared with healthy women. Besides, regression models show that different covariates, such as age, cognitive impairment, or depression, are related to specific subfields.
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