Journal
CURRENT OPINION IN VIROLOGY
Volume 46, Issue -, Pages 15-19Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2020.08.005
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Funding
- N.I.H.NIAID grant [R01 AI74668, T32 AI007520]
- Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases Award
- Faculty Scholar grant from the Howard Hughes Medical Institute
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Enteric viruses are significant human pathogens that infect the gastrointestinal tract, where the microbiota play a crucial role in their replication, pathogenesis, and transmission. The abundance and composition of the microbiota are also important for the host immune system, which may impact the infection of enteric viruses.
Enteric viruses are important human pathogens that pose a significant global health problem. These viruses infect the gastrointestinal tract, which contains a community of microbes called the 'microbiota'. We and others have shown that intestinal microbiota are crucial for the replication, pathogenesis, and transmission of a variety of enteric viruses. However, the mechanisms underlying microbiota enhancement of enteric virus infection remain unclear. Interestingly, the host immune system is dependent on both the abundance and composition of the intestinal microbiota. Here we review several aspects of how microbiota influence the immune system and how this could potentially impact enteric virus infection.
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