Jack-of-all-trades: itaconate tolerizes NLRP3 inflammasome activation

Immune responses must be tightly regulated in order to avoid excessive inflammation. In this issue of Cell Reports, Bambouskova et al. (2021) demonstrate that itaconate and iNOS collaborate to tolerize the NLRP3 inflammasome, thereby limiting cytokine secretion and cell death.

Automated summary

Itaconate and iNOS work together to regulate NLRP3 inflammasome activity, reducing cytokine secretion and cell death.