Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia

The magneto-thermal effect, which represents the conversion of magnetostatic energy to heat from magnetic materials, has been spotlighted for potential therapeutic usage in hyperthermia treatments. However, the realization of its potential has been challenged owing to the limited heating from the magnetic nanoparticles. Here, we explored a new-concept of magneto-thermal modality marked by low-power-driven, fast resonant spin-excitation followed by consequent energy dissipation, which concept has yet to be realized for current hyperthermia applications. We investigated the effect of spin resonance-mediated heat dissipation using superparamagnetic Fe3O4 nanoparticles and achieved an extraordinary initial temperature increment rate of more than 150 K/s, which is a significant increase in comparison to that for the conventional magnetic heat induction of nanoparticles. This work would offer highly efficient heat generation and precision wireless controllability for realization of magnetic-hyperthermia-based medical treatment.

Automated summary

The magneto-thermal effect, which converts magnetostatic energy to heat from magnetic materials, has potential therapeutic usage in hyperthermia treatments. However, the limited heating from magnetic nanoparticles has challenged its realization. This study explores a new concept of magneto-thermal modality with fast resonant spin-excitation for efficient heat generation and wireless controllability.