Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-021-83093-4
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Funding
- National Health and Medical Research Council of Australia (NHMRC) [APP1143946]
- NHMRC [APP1092789]
- NHMRC Career Development Fellowship [APP1140509]
- Bill & Melinda Gates Foundation [46099]
- Medical Research Foundation for Women and Babies
- Mercy Research Foundation
- NHMRC Investigator Fellowship [1173871]
- University of Melbourne Dame Kate Campbell Fellowship
- National Health and Medical Research Council of Australia [1173871] Funding Source: NHMRC
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The study investigated the impact of antibodies in pregnant women on malaria during pregnancy, finding that the anti-inflammatory effect of antibodies during pregnancy may weaken the immune response to placental malaria.
Immune effector responses against Plasmodium falciparum include antibody-mediated activation of innate immune cells, which can induce Fc effector functions, including antibody-dependent cellular cytotoxicity, and the secretion of cytokines and chemokines. These effector functions are regulated by the composition of immunoglobulin G (IgG) Fc N-linked glycans. However, a role for antibody-mediated natural killer (NK) cells activation or Fc N-linked glycans in pregnant women with malaria has not yet been established. Herein, we studied the capacity of IgG antibodies from pregnant women, with placental malaria or non-placental malaria, to induce NK cell activation in response to placental malaria-associated antigens DBL2 and DBL3. Antibody-mediated NK cell activation was observed in pregnant women with malaria, but no differences were associated with susceptibility to placental malaria. Elevated anti-inflammatory glycosylation patterns of IgG antibodies were observed in pregnant women with or without malaria infection, which were not seen in healthy non-pregnant controls. This suggests that pregnancy-associated anti-inflammatory Fc N-linked glycans may dampen the antibody-mediated activation of NK cells in pregnant women with malaria infection. Overall, although anti-inflammatory glycans and antibody-dependent NK cell activation were detected in pregnant women with malaria, a definitive role for these antibody features in protecting against placental malaria remains to be proven.
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