Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-82522-8
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Funding
- Canada Mink Breeders Association
- Nova Scotia Mink Breeders Association
- Fur Farmers of Canada Marketing Association
- American Legend Cooperatives
- North American Fur Auctions
- American Mink Council
- American Mink Farmers Research Foundation
- Agriculture and Agri-Food Canada through the CARD Councils of Ontario
- British Columbia
- Nova Scotia (Agri-Futures NS)
- Atlantic Innovation Fund of Atlantic Opportunity Agency
- Technology Development Program of the Nova Scotia Department of Agriculture
- Agriculture and Agri-Food Canada through the Canadian Agricultural Adaptation Program of Nova Scotia (Agri-Futures Nova Scotia)
- Mitacs Accelerate Award
- NSERC
- Compute Canada-Resources for Research Group
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This study identified genomic regions in American mink that are under selection in response to infection with Aleutian mink disease virus (AMDV), revealing genes related to immune response, liver development, and reproduction. Two strongly selected regions containing candidate genes related to immune response, virus-host interaction, reproduction, and liver regeneration were supported by hapFLK test.
Aleutian disease (AD) is the most significant health issue for farmed American mink. The objective of this study was to identify the genomic regions subjected to selection for response to infection with Aleutian mink disease virus (AMDV) in American mink using genotyping by sequencing (GBS) data. A total of 225 black mink were inoculated with AMDV and genotyped using a GBS assay based on the sequencing of ApeKI-digested libraries. Five AD-characterized phenotypes were used to assign animals to pairwise groups. Signatures of selection were detected using integrated measurement of fixation index (F-ST) and nucleotide diversity (theta pi), that were validated by haplotype-based (hap-FLK) test. The total of 99 putatively selected regions harbouring 63 genes were detected in different groups. The gene ontology revealed numerous genes related to immune response (e.g. TRAF3IP2, WDR7, SWAP70, CBFB, and GPR65), liver development (e.g. SULF2, SRSF5) and reproduction process (e.g. FBXO5, CatSper beta, CATSPER4, and IGF2R). The hapFLK test supported two strongly selected regions that contained five candidate genes related to immune response, virus-host interaction, reproduction and liver regeneration. This study provided the first map of putative selection signals of response to AMDV infection in American mink, bringing new insights into genomic regions controlling the AD phenotypes.
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