Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-021-83059-6
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Funding
- Department of Physiology, Development and Neuroscience
- Evelyn Trust
- MRC Confidence in Concept Fund
- Cambridge Hearing Trust
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The study presents a fast, practicable and freely available method for estimating cochlear size and shape from clinical CT images. By fitting a template surface to the CT data, measurements of cochlear size, duct length, and a novel measure of basal turn non-planarity are obtained, which could potentially correlate with the risk of insertion trauma. The method yields promising results, with the locally affine deformation (LAD) method showing the best performance.
There is considerable interpersonal variation in the size and shape of the human cochlea, with evident consequences for cochlear implantation. The ability to characterize a specific cochlea, from preoperative computed tomography (CT) images, would allow the clinician to personalize the choice of electrode, surgical approach and postoperative programming. In this study, we present a fast, practicable and freely available method for estimating cochlear size and shape from clinical CT. The approach taken is to fit a template surface to the CT data, using either a statistical shape model or a locally affine deformation (LAD). After fitting, we measure cochlear size, duct length and a novel measure of basal turn non-planarity, which we suggest might correlate with the risk of insertion trauma. Gold-standard measurements from a convenience sample of 18 micro-CT scans are compared with the same quantities estimated from low-resolution, noisy, pseudo-clinical data synthesized from the same micro-CT scans. The best results were obtained using the LAD method, with an expected error of 8-17% of the gold-standard sample range for non-planarity, cochlear size and duct length.
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