Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41598-021-84209-6
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Funding
- Research Council of Iran University of Science and Technology (IUST), Tehran, Iran
- Iran Nanotechnology Initiative Council (INIC), Iran
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A library of new compounds have been prepared efficiently using a one-pot method mediated by a reusable catalyst, showing excellent yields and environmental benefits, with potential applications in pharmaceutical chemistry.
A library of new spiro[diindeno[1,2-b:2 ' ,1 ' -e]pyridine-11,3 ' -indoline]-2 ' ,10,12-trione derivatives has been prepared in an efficient, one-pot pseudo four-component method mediated by a reusable heterogeneous nano-ordered mesoporous SO3H functionalized-silica (MCM-41-SO3H) catalyst. Excellent yields, short reaction times, as well as convenient non-chromatographic purification of the products and environmental benefits such as green and metal-free conditions constitute the main advantages of the developed synthetic methodology. The obtained fused indole-indenone dyes would be of interest to pharmaceutical and medicinal chemistry. Furthermore, due to their sensitivity to pH changes, they could be used as novel pH indicators.
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