Journal
SCIENTIFIC REPORTS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-80425-8
Keywords
-
Categories
Funding
- State Key Laboratory of Military Stomatology Open project [2018KA01]
- Scientific and technological research projects on major issues in aviation medicine from school [2019ZTC03]
- National Natural Science Foundation of China [81870415]
- Key R&D Projects in Shaanxi Province [2018ZDXM-SF-082, 2018JZ8003]
Ask authors/readers for more resources
The study demonstrated that a single exposure to mild or severe hypobaric hypoxia could improve performance in healthy mice. In the cerebellum, 6 out of 8 detected genes showed no change after SHH, while in the hippocampus all genes remained unchanged. In the muscles, 7 out of 8 detected genes did not show any changes after SHH exposure.
Simulated hypobaric hypoxia (SHH) training has been used to enhance running performance. However, no studies have evaluated the effects of a single SHH exposure on healthy mice performance and analyzed the changes of mitochondria-related genes in the central nervous system. The current study used a mouse decompression chamber to simulate mild hypobaric hypoxia at the high altitude of 5000 m or severe hypobaric hypoxia at 8000 m for 16 h (SHH5000 & SHH8000, respectively). Then, the mouse behavioral tests were recorded by a modified Noldus video tracking. Third, the effects of SHH on 8 mitochondria-related genes of Drp1, Mfn1, Mfn2, Opa1, TFAM, SGK1, UCP2 and UCP4, were assessed in cerebellum, hippocampus and gastrocnemius muscles. The results have shown that a single mild or severe HH improves healthy mice performance. In cerebellum, 6 of all 8 detected genes (except Mfn2 and UCP4) did not change after SHH. In hippocampus, all detected genes did not change after SHH. In muscles, 7 of all 8 detected genes (except Opa1) did not change after SHH. The present study has indicated the benefit of a single SHH in healthy mice performance, which would due to the stabilized mitochondria against a mild stress state.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available