Journal
BRAIN
Volume 138, Issue -, Pages 2293-2309Publisher
OXFORD UNIV PRESS
DOI: 10.1093/brain/awv114
Keywords
multiple system atrophy; alpha-synuclein; neuropathology; Lewy body-like; inclusion bodies
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Funding
- National Institutes of Health [P01 NS044233, U54NSO65736]
- Kathy Shih Memorial Foundation
- Mayo funds
- Cure PSP Foundation
- Multiple System Atrophy Coalition
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Multiple system atrophy (MSA) is characterized clinically by parkinsonism, cerebellar dysfunction, and dysautonomia, and pathologically by glial cytoplasmic inclusions. Using pathological and clinical data from 35 patients, Cykowski et al. expand the spectrum of neuronal pathology in MSA and argue that neuronal inclusions have a key role in disease pathogenesis.See Halliday (doi:10.1093/brain/awv151) for a scientific commentary on this article. Multiple system atrophy (MSA) is characterized clinically by parkinsonism, cerebellar dysfunction, and dysautonomia, and pathologically by glial cytoplasmic inclusions. Using pathological and clinical data from 35 patients, Cykowski et al. expand the spectrum of neuronal pathology in MSA and argue that neuronal inclusions have a key role in disease pathogenesis.See Halliday (doi:10.1093/brain/awv151) for a scientific commentary on this article.
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