Journal
MATERIALS
Volume 14, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ma14051067
Keywords
fungal retarding; biofilm adhesion; Candida albicans; denture stomatitis; protein repellent; solution pH; surface roughness
Categories
Funding
- Research Center of the Female Scientific and Medical Colleges, Deanship of Scientific Research, King Saud University
Ask authors/readers for more resources
This study aimed to investigate the effects of incorporating MPC into a new HIPA resin on the surface roughness, solution pH, and C. albicans biofilm adhesion to denture base. The results showed that incorporating 4.5% MPC led to a significant reduction in colony-forming units compared to the control group.
Candida albicans (C. albicans) biofilm is a common etiological factor in denture stomatitis. The purpose of this study was to investigate the effects of incorporating 2-methacryloyloxyethyl phosphorylcholine (MPC) as a protein repellent into a new high-impact denture acrylic (HIPA) resin on the surface roughness, solution pH, and C. albicans biofilm adhesion to the denture base. The new acrylic denture resin base was formulated by mixing MPC into HIPA resin at mass fractions of 1.5%, 3%, and 4.5%. Surface roughness was measured using a Mitutoyo surface roughness tester. C. albicans biofilm growth and viability were assessed via colony forming unit counts. The pH of the biofilm growth medium was measured using a digital pH meter. Adding MPC to the HIPA resin at percentages of 1.5% and 3% increased the roughness values significantly (p < 0.05), while adding 4.5% MPC resulted in no difference in roughness values to that of the control group (p > 0.05). All experimental groups demonstrated neutral pH values (pH approximately equal to 7) and were not significantly different from each other (p > 0.05). Incorporating 2-methacryloyloxyethyl phosphorylcholine at 4.5% resulted in a significant ( approximately equal to 1 log) colony-forming unit reduction compared with the control group with 0% MPC (p < 0.05). A fungal-retarding denture acrylic resin was developed through the incorporation of MPC for its protein-repelling properties. This newly developed denture acrylic material has the potential to prevent oral microbial infections, such as denture stomatitis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available