Coumarin derivatives as promising antibacterial agent(s)

Nowadays, bacterial infections epitomize significant health threats globally with an increased morbidity and mortality. Most contemporary antibacterial agents are resisted by pathogenic bacteria - the multidrug resistant (MDR) bacterial strains arising from cross resistances operative in natural bacterial consortia inside human body and in environments. Consequently, the development of newer potential drug candidate(s) is required against the broad spectrum of MDR bacteria. Indeed, the phytochemical coumarin and its derivatives had been reported with broad biological inhibitory properties, including antibacterial activities. In this review, several methods of synthetic strategies of coumarin derivatives as antibacterials were considered with individual schematic compounds by structure-activity relationship (SAR) studies as essential corollaries. Overall, substituents at positions C-3 and C-4 of coumarin are coveted for the development of newer antibacterial agents. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

Automated summary

Bacterial infections are significant health threats worldwide, with antibiotic resistance posing a challenge. The development of new potential drug candidates is necessary to combat multidrug-resistant bacteria. Coumarin and its derivatives have been reported to have broad inhibitory properties, with substituents at positions C-3 and C-4 shown to be coveted for the development of newer antibacterial agents.