被撤回的出版物: Two new coordination polymers: Magnetic properties and treatment activity on non-small cell lung cancer by reversing the resistance of the cancer cells (Retracted article. See vol. 16, 2023)

In the current study, by employing 5-((4-carboxypyridin-2-yl)amino)isophthalic acid (H3L), a semirigid carboxylate-pyridine ligand with V-shape, two new transition metal coordination polymers with the chemical formulae of [Cu-1.5(L)(H2O)]center dot 2H(2)O (1) and [Co-4(L)(2)(CH3CN)(OH)(2)(H-2-O)(4)]center dot 3H(2)O(2) have been successfully prepared through the reaction between the H 3 L ligand and corresponding metal salts under the solvothermal reaction conditions. Magnetic investigations have suggested that there is antiferromagnetic coupling between neighboring metal ions in the two compounds. The application values of compounds 1 and 2 on the non-small cell lung cancer (NSCLC) was evaluated and the related mechanism was discussed at the same time. First of all, the Cell Counting Kit-8 (CCK-8) detection kit was performed to measure the viability of the non-small cell lung cancer cells after compound treatment. In addition to this, the real time reverse transcription polymerase chain reaction (real time RT-PCR) was used to detect the relative expression levels of the ezh2 gene in NSCLC cells after indicated treatment. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

Automated summary

This study synthesized two new transition metal coordination polymers with antiferromagnetic coupling, and evaluated their application on non-small cell lung cancer while discussing the related mechanism. The compounds were tested for their viability on NSCLC cells and the expression levels of the ezh2 gene were detected after treatment.