Journal
ACS CATALYSIS
Volume 11, Issue 6, Pages 3218-3223Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.1c00090
Keywords
silver; dibromotrifluoromethoxylation; trifunctionalization; terminal alkynes; synthetic method
Categories
Funding
- National Key Research and Development Program of China [2016YFA0602900]
- NFSC [21672110, 21925105]
- Natural Science Foundation of Tianjin [18JCJQJC47000]
- NCC Fund [NCC2020FH07]
- Fundamental Research Funds for the Central Universities
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The silver-catalyzed dibromotrifluoromethoxylation of terminal alkynes reported provides 1,1-dibromo-2-(trifluoromethoxy)alkenes in good yields and high regioselectivity under mild reaction conditions. The reaction has a broad substrate scope and can be used for late-stage trifluoromethoxylation of complex small molecules. The products can be further modified, offering a convenient method for synthesizing compounds containing the OCF3 group.
A silver-catalyzed dibromotrifluoromethoxylation of terminal alkynes has been reported, which provides the corresponding 1,1-dibromo-2-(trifluoromethoxy)alkenes in good yields and high regioselectivity under mild reaction conditions. The reaction exhibits a broad substrate scope and applies to late-stage trifluoromethoxylation of complex small molecules. Moreover, the products can he further modified, which provides a convenient method for the synthesis of compounds containing the OCF3 group.
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