Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-21574-w
Keywords
-
Categories
Funding
- US National Institutes of Health [R01 AI71922, AI105215, AI137230, R01 AI040127, AI109842, T32 AI125179]
- Shared Instrumentation Grant (SIG) Program [S10 OD018499, S10 RR027366, S10 OD016262, S10 OD025052]
Ask authors/readers for more resources
The study found that iNKT cell subsets are similar regardless of tissue location, with lung iNKT cells possessing the most distinct location-specific features possibly due to increased activation. Following antigenic stimulation, iNKT cells undergo chromatin and transcriptional changes, giving rise to additional subsets.
Invariant natural killer T cells (iNKT cells) differentiate into thymic and peripheral NKT1, NKT2 and NKT17 subsets. Here we use RNA-seq and ATAC-seq analyses and show iNKT subsets are similar, regardless of tissue location. Lung iNKT cell subsets possess the most distinct location-specific features, shared with other innate lymphocytes in the lung, possibly consistent with increased activation. Following antigenic stimulation, iNKT cells undergo chromatin and transcriptional changes delineating two populations: one similar to follicular helper T cells and the other NK or effector like. Phenotypic analysis indicates these changes are observed long-term, suggesting that iNKT cells gene programs are not fixed, but they are capable of chromatin remodeling after antigen to give rise to additional subsets. Invariant natural killer T cells are known to be composed of a number of phenotypic and functionally distinct populations. Here the authors use transcriptomic and epigenomic analysis to further characterize the peripheral iNKT compartment before and after antigenic stimulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available