Reward-related choices determine information timing and flow across macaque lateral prefrontal cortex

Prefrontal cortex is critical for cognition. Although much is known about the representation of cognitive variables in the prefrontal cortex, much less is known about the spatio-temporal neural dynamics that underlie cognitive operations. In the present study, we examined information timing and flow across the lateral prefrontal cortex (LPFC), while monkeys carried out a two-armed bandit reinforcement learning task in which they had to learn to select rewarding actions or rewarding objects. When we analyzed signals independently within subregions of the LPFC, we found a task-specific, caudo-rostral gradient in the strength and timing of signals related to chosen objects and chosen actions. In addition, when we characterized information flow among subregions, we found that information flow from action to object representations was stronger from the dorsal to ventral LPFC, and information flow from object to action representations was stronger from the ventral to dorsal LPFC. The object to action effects were more pronounced in object blocks, and also reflected learning specifically in these blocks. These results suggest anatomical segregation followed by the rapid integration of information within the LPFC. Previous studies provided conflicting evidence on the functional organization of the lateral prefrontal cortex. The authors show task-specific information flows along the caudo-rostral and dorso-ventral axes, reflecting the cognitive process of identifying the location or identity of a valuable object.

Automated summary

This study revealed the spatio-temporal distribution of information in the prefrontal cortex, uncovering task-specific signal flows and indicating anatomical segregation followed by rapid integration of information within the LPFC.