Perspectives on skeletal muscle stem cells

Skeletal muscle has remarkable regeneration capabilities, mainly due to its resident muscle stem cells (MuSCs). In this review, we introduce recently developed technologies and the mechanistic insights they provide to the understanding of MuSC biology, including the re-definition of quiescence and G(alert) states. Additionally, we present recent studies that link MuSC function with cellular heterogeneity, highlighting the complex regulation of self-renewal in regeneration, muscle disorders and aging. Finally, we discuss MuSC metabolism and its role, as well as the multifaceted regulation of MuSCs by their niche. The presented conceptual advances in the MuSC field impact on our general understanding of stem cells and their therapeutic use in regenerative medicine. Skeletal muscle has a remarkable regenerative capacity, which can largely be attributed to resident muscle stem cells (MuSCs). Here, the authors review the molecular mechanisms regulating MuSC quiescence, activation and proliferation, how these processes are regulated by the stem cell niche, and the role of MuSCs in neuromuscular diseases.

Automated summary

Skeletal muscle possesses remarkable regenerative capabilities, mainly attributed to its resident muscle stem cells. Recent technological advancements have provided mechanistic insights into MuSC biology, emphasizing their role in regeneration, muscle disorders, and aging. The complex regulation of MuSCs by their niche and the understanding of their metabolic role impact the broader understanding of stem cells and their therapeutic applications in regenerative medicine.