Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE RESEARCH
DOI: 10.1038/s41467-021-21298-x
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Funding
- NIMH [RF1 MH117155, T32 MH020002]
- ONR-MURI [N00014-16-1-2829]
- NIBIB [R01 EB009282]
- Kavli Institute for Brain and Mind
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Research shows that there is a strong tonic and phase-locked increase in firing and co-firing during spindles, especially those occurring with down-to-upstate transitions, within 25 ms. Co-firing, spindle co-occurrence, and spindle coherence are greatest within approximately 2 mm.
Sleep spindles facilitate memory consolidation in the cortex during mammalian non-rapid eye movement sleep. In rodents, phase-locked firing during spindles may facilitate spike-timing-dependent plasticity by grouping pre-then-post-synaptic cell firing within similar to 25 ms. Currently, microphysiological evidence in humans for conditions conducive for spike-timing-dependent plasticity during spindles is absent. Here, we analyze field potentials and unit firing from middle/upper layers during spindles from 10 x 10 microelectrode arrays at 400 mu m pitch in humans. We report strong tonic and phase-locked increases in firing and co-firing within 25 ms during spindles, especially those co-occurring with down-to-upstate transitions. Co-firing, spindle co-occurrence, and spindle coherence are greatest within similar to 2 mm, and high co-firing of units on different contacts depends on high spindle coherence between those contacts. Spindles propagate at similar to 0.28 m/s in distinct patterns, with correlated cell co-firing sequences. Spindles hence organize spatiotemporal patterns of neuronal co-firing in ways that may provide pre-conditions for plasticity during non-rapid eye movement sleep.
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