Journal
ONCOLOGY LETTERS
Volume 21, Issue 4, Pages -Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2021.12563
Keywords
HOX antisense intergenic RNA; tumour metastasis; TGF-beta signalling pathway; Wnt/beta-catenin signalling pathway; PI3K; AKT; MAPK signal pathway; VEGF signalling pathway
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Funding
- National Natural Science Foundation of China [81904129]
- Shanghai Pudong New Area Health Commission's 2019 Joint Public Relations Project [PW2019D-7]
- three-year action plan for further accelerating the development of Chinese medicine in Shanghai [2018-2020, ZY(2018-2020) -ZYBZ-01]
- 2019 Shanghai Chinese and Western Medicine Clinical Collaboration Pilot Project Funding [ZXYXZ-201909]
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This review provides a summary of the molecular mechanism and role of HOTAIR in tumor invasion and metastasis, discusses its association with tumor metastasis through various pathways, and emphasizes its function in human malignant tumor metastasis.
Long non-coding RNA (lncRNA) is a new type of non-coding RNA that has an important regulatory influence on several human diseases, including cancer metastasis. HOX antisense intergenic RNA (HOTAIR), a newly discovered lncRNA, has an important effect on tumour proliferation, migration and metastasis. HOTAIR regulates cell proliferation, changes gene expression, and promotes tumour cell invasion and migration. However, its molecular mechanism of action remains unknown. The present review summarizes the molecular mechanism and role of HOTAIR in tumour invasion and metastasis, discusses the association between HOTAIR and tumour metastasis through different pathways, such as the transforming growth factor beta, Wnt/beta-catenin, PI3K/AKT/MAPK and vascular endothelial growth factor pathways, emphasizes the function of HOTAIR in human malignant tumour metastasis and provides a foundation for its application in the diagnosis, prognosis and medical treatment of various tumours.
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