4.7 Review

Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

A Bile Duct-on-a-Chip With Organ-Level Functions

Yu Du et al.

HEPATOLOGY (2020)

Review Urology & Nephrology

The present and future of transplant organ shortage: some potential remedies

Bahar Bastani

JOURNAL OF NEPHROLOGY (2020)

Article Cell Biology

Bio-ink development for three-dimensional bioprinting of hetero-cellular cartilage constructs

Vivian H. M. Mouser et al.

CONNECTIVE TISSUE RESEARCH (2020)

Article Materials Science, Multidisciplinary

Probing the Ultrastructure of Spheroids and Their Uptake of Magnetic Nanoparticles by FIB-SEM

Valentina Mollo et al.

ADVANCED MATERIALS TECHNOLOGIES (2020)

Article Engineering, Biomedical

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

Richard Novak et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Article Engineering, Biomedical

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Anna Herland et al.

NATURE BIOMEDICAL ENGINEERING (2020)

Review Chemistry, Multidisciplinary

Bioprinting: From Tissue and Organ Development to in Vitro Models

Carlos Mota et al.

CHEMICAL REVIEWS (2020)

Article Biotechnology & Applied Microbiology

Hybrid Bioprinting of Chondrogenically Induced Human Mesenchymal Stem Cell Spheroids

Lise De Moor et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Feasibility of the taylor vortex flow bioreactor for mesenchymal stromal cell expansion on microcarriers

Liseth Viviana Gonzalez Gil et al.

BIOCHEMICAL ENGINEERING JOURNAL (2020)

Article Engineering, Biomedical

Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfaces

Paweena Diloksumpan et al.

BIOFABRICATION (2020)

Article Biotechnology & Applied Microbiology

A systematic mass-transfer modeling approach for mammalian cell culture bioreactor scale-up

Chuan He et al.

BIOCHEMICAL ENGINEERING JOURNAL (2019)

Article Computer Science, Interdisciplinary Applications

A parallel Voronoi-based approach for mesoscale simulations of cell aggregate electropermeabilization

Pouria Mistani et al.

JOURNAL OF COMPUTATIONAL PHYSICS (2019)

Article Chemistry, Multidisciplinary

Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release

Pooja Sabhachandani et al.

JOURNAL OF CONTROLLED RELEASE (2019)

Article Biochemistry & Molecular Biology

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Oded Kopper et al.

NATURE MEDICINE (2019)

Article Chemistry, Multidisciplinary

3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

Nadav Noor et al.

ADVANCED SCIENCE (2019)

Review Cell & Tissue Engineering

Review on biofabrication and applications of heterogeneous tumor models

Tiankun Liu et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

Review Multidisciplinary Sciences

Organoids-on-a-chip

Sunghee Estelle Park et al.

SCIENCE (2019)

Article Biotechnology & Applied Microbiology

Proteomic Identification and Time-Course Monitoring of Secreted Proteins During Expansion of Human Mesenchymal Stem/Stromal in Stirred-Tank Bioreactor

Amanda Mizukami et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Article Biotechnology & Applied Microbiology

Self-organizing neuruloids model developmental aspects of Huntington's disease in the ectodermal compartment

Tomomi Haremaki et al.

NATURE BIOTECHNOLOGY (2019)

Review Biotechnology & Applied Microbiology

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Ana S. Nunes et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

Review Biotechnology & Applied Microbiology

New generation of bioreactors that advance extracellular matrix modelling and tissue engineering

Shehnaz Ahmed et al.

BIOTECHNOLOGY LETTERS (2019)

Article Automation & Control Systems

Rheological evaluation of Laponite/alginate inks for 3D extrusion-based printing

Jose Luis Davila et al.

INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY (2019)

Article Engineering, Biomedical

Bioprinting of 3D breast epithelial spheroids for human cancer models

Swathi Swaminathan et al.

BIOFABRICATION (2019)

Article Biochemistry & Molecular Biology

Breast cancer stem cells are involved in Trastuzumab resistance through the HER2 modulation in 3D culture

Cristina E. Rodriguez et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Biotechnology & Applied Microbiology

Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications

Hsin-Pei Shih et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Anatomy & Morphology

Dissociation of mono- and co-culture spheroids into single cells for subsequent flow cytometric analysis

Ute Graesser et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2018)

Article Biotechnology & Applied Microbiology

DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein

Monize Caiado Decarli et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2018)

Article Biotechnology & Applied Microbiology

Technologies for large-scale umbilical cord-derived MSC expansion: Experimental performance and cost of goods analysis

Amanda Mizukami et al.

BIOCHEMICAL ENGINEERING JOURNAL (2018)

Article Biochemical Research Methods

Engineered microfluidic bioreactor for examining the three-dimensional breast tumor microenvironment

Matthew Rogers et al.

BIOMICROFLUIDICS (2018)

Article Biophysics

Coherent Timescales and Mechanical Structure of Multicellular Aggregates

Miao Yu et al.

BIOPHYSICAL JOURNAL (2018)

Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

Article Biochemistry & Molecular Biology

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

Suk Hyung Lee et al.

Review Cell & Tissue Engineering

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

Kacey Ronaldson-Bouchard et al.

CELL STEM CELL (2018)

Review Oncology

Liver 'organ on a chip'

Colin H. Beckwitt et al.

EXPERIMENTAL CELL RESEARCH (2018)

Article Ophthalmology

3D bioprinting of a corneal stroma equivalent

Abigail Isaacson et al.

EXPERIMENTAL EYE RESEARCH (2018)

Review Chemistry, Multidisciplinary

Application of 3D cultured multicellular spheroid tumor models in tumor-targeted drug delivery system research

Bu-Wei Huang et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Article Oncology

Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma

Yeonhwa Song et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

Article Engineering, Biomedical

Fabrication of agarose concave petridish for 3D-culture microarray method for spheroids formation of hepatic cells

Binbin Zhang et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2018)

Article Biology

Viscoelastic modeling of the fusion of multicellular tumor spheroids in growth phase

Guillaume Dechriste et al.

JOURNAL OF THEORETICAL BIOLOGY (2018)

Article Biochemical Research Methods

Mass Spectrometry Imaging of 3D Tissue Models

Cristina Russo et al.

PROTEOMICS (2018)

Article Multidisciplinary Sciences

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Georgios Vlachogiannis et al.

SCIENCE (2018)

Article Chemistry, Analytical

Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture

Khashayar Moshksayan et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Article Toxicology

High-content imaging assays on a miniaturized 3D cell culture platform

Pranav Joshi et al.

TOXICOLOGY IN VITRO (2018)

Review Biotechnology & Applied Microbiology

Biofabrication: A Guide to Technology and Terminology

Lorenzo Moroni et al.

TRENDS IN BIOTECHNOLOGY (2018)

Article Multidisciplinary Sciences

TASI: A software tool for spatial-temporal quantification of tumor spheroid dynamics

Yue Hou et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Facile Tumor Spheroids Formation in Large Quantity with Controllable Size and High Uniformity

Wentao Shi et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Automated brightfield morphometry of 3D organoid populations by OrganoSeg

Michael A. Borten et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

A high-throughput imaging and nuclear segmentation analysis protocol for cleared 3D culture models

Molly E. Boutin et al.

SCIENTIFIC REPORTS (2018)

Review Cell & Tissue Engineering

Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization

Amanda Mizukami et al.

STEM CELLS INTERNATIONAL (2018)

Article Multidisciplinary Sciences

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Tao Jiang et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2018)

Review Pharmacology & Pharmacy

Drug metabolism in drug discovery and development

Zhoupeng Zhang et al.

ACTA PHARMACEUTICA SINICA B (2018)

Article Biochemistry & Molecular Biology

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Huili Hu et al.

Article Multidisciplinary Sciences

Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture

Shuang Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Oncology

Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

Article Public, Environmental & Occupational Health

Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids

Steven D. Forsythe et al.

FRONTIERS IN PUBLIC HEALTH (2018)

Review Gastroenterology & Hepatology

Engineered Livers for Infectious Diseases

Nil Gural et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Engineering, Biomedical

Fabrication of biomimetic placental barrier structures within a microfluidic device utilizing two-photon polymerization

Denise Mandt et al.

INTERNATIONAL JOURNAL OF BIOPRINTING (2018)

Article Multidisciplinary Sciences

Optimized alamarBlue assay protocol for drug dose-response determination of 3D tumor spheroids

Christoph Eilenberger et al.

METHODSX (2018)

Article Engineering, Biomedical

High-throughput fabrication of vascularized spheroids for bioprinting

Lise De Moor et al.

BIOFABRICATION (2018)

Article Cell & Tissue Engineering

Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures

Sofia P. Rebelo et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

Review Biochemistry & Molecular Biology

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

S. Chouaib et al.

ONCOGENE (2017)

Review Medicine, Research & Experimental

Next generation human skin constructs as advanced tools for drug development

H. E. Abaci et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Review Oncology

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

Stephen Riffle et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Article Multidisciplinary Sciences

Measurement of oxygen tension within mesenchymal stem cell spheroids

Kaitlin C. Murphy et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2017)

Review Multidisciplinary Sciences

Advances in multicellular spheroids formation

X. Cui et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2017)

Article Multidisciplinary Sciences

In-depth phenotypic characterization of multicellular tumor spheroids: Effects of 5-Fluorouracil

Angelique Virgone-Carlotta et al.

PLOS ONE (2017)

Review Biotechnology & Applied Microbiology

Life is 3D: Boosting Spheroid Function for Tissue Engineering

Matthias W. Laschke et al.

TRENDS IN BIOTECHNOLOGY (2017)

Article Biology

Enhanced FIB-SEM systems for large-volume 3D imaging

C. Shan Xu et al.

ELIFE (2017)

Article Multidisciplinary Sciences

Preparation and Metabolic Assay of 3-dimensional Spheroid Co-cultures of Pancreatic Cancer Cells and Fibroblasts

Pawan Noel et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2017)

Article Oncology

High-Content Monitoring of Drug Effects in a 3D Spheroid Model

Frederique Mittler et al.

FRONTIERS IN ONCOLOGY (2017)

Article Multidisciplinary Sciences

Spheroid arrays for high-throughput single-cell analysis of spatial patterns and biomarker expression in 3D

Delyan P. Ivanov et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Aleksander Skardal et al.

SCIENTIFIC REPORTS (2017)

Review Developmental Biology

Embryoids, organoids and gastruloids: new approaches to understanding embryogenesis

Mijo Simunovic et al.

DEVELOPMENT (2017)

Review Developmental Biology

The hope and the hype of organoid research

Meritxell Huch et al.

DEVELOPMENT (2017)

Review Developmental Biology

Lung organoids: current uses and future promise

Christina E. Barkauskas et al.

DEVELOPMENT (2017)

Article Engineering, Biomedical

3D bioprinting of functional human skin: production and in vivo analysis

Nieves Cubo et al.

BIOFABRICATION (2017)

Article Chemistry, Multidisciplinary

Directed Assembly and Development of Material-Free Tissues with Complex Architectures

Erik Vrij et al.

ADVANCED MATERIALS (2016)

Article Biochemistry & Molecular Biology

Organoids as a model system for studying human lung development and disease

Rohan R. Nadkarni et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Biotechnology & Applied Microbiology

3D tumor spheroids: an overview on the tools and techniques used for their analysis

Elisabete C. Costa et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

Review Pharmacology & Pharmacy

The development of high-content screening (HCS) technology and its importance to drug discovery

Ivan Fraietta et al.

EXPERT OPINION ON DRUG DISCOVERY (2016)

Article Biotechnology & Applied Microbiology

Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models

Vitor E. Santo et al.

JOURNAL OF BIOTECHNOLOGY (2016)

Article Economics

Innovation in the pharmaceutical industry: New estimates of R&D costs

Joseph A. DiMasi et al.

JOURNAL OF HEALTH ECONOMICS (2016)

Article Biochemical Research Methods

3D high throughput screening and profiling of embryoid bodies in thermoformed microwell plates

E. J. Vrij et al.

LAB ON A CHIP (2016)

Article Biochemical Research Methods

Rapid formation of size-controllable multicellular spheroids via 3D acoustic tweezers

Kejie Chen et al.

LAB ON A CHIP (2016)

Article Biotechnology & Applied Microbiology

A 3D bioprinting system to produce human-scale tissue constructs with structural integrity

Hyun-Wook Kang et al.

NATURE BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

Two-Photon Microscopy Analysis of Gold Nanoparticle Uptake in 3D Cell Spheroids

Tushar D. Rane et al.

PLOS ONE (2016)

Article Cell & Tissue Engineering

Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique

Matthew J. Ware et al.

TISSUE ENGINEERING PART C-METHODS (2016)

Article Engineering, Biomedical

Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors

Stephanie L. Ham et al.

ADVANCED HEALTHCARE MATERIALS (2016)

Article Medicine, General & Internal

Failure of Investigational Drugs in Late-Stage Clinical Development and Publication of Trial Results

Thomas J. Hwang et al.

JAMA INTERNAL MEDICINE (2016)

Review Cell & Tissue Engineering

Spheroid Culture of Mesenchymal Stem Cells

Zoe Cesarz et al.

STEM CELLS INTERNATIONAL (2016)

Article Materials Science, Biomaterials

Rapid Enhancement of Cellular Spheroid Assembly by Acoustically Driven Microcentrifugation

Layla Alhasan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Article Materials Science, Biomaterials

Rapid Enhancement of Cellular Spheroid Assembly by Acoustically Driven Microcentrifugation

Layla Alhasan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Article Multidisciplinary Sciences

Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress

Carman K. M. Ip et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

The effects of hypoxia on the stemness properties of human dental pulp stem cells (DPSCs)

Nermeen El-Moataz Bellah Ahmed et al.

SCIENTIFIC REPORTS (2016)

Article Engineering, Biomedical

Biofabrication: reappraising the definition of an evolving field

Juergen Groll et al.

BIOFABRICATION (2016)

Article Biochemical Research Methods

High-Content Assays for Characterizing the Viability and Morphology of 3D Cancer Spheroid Cultures

Oksana Sirenko et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2015)

Review Oncology

Maintaining Tumor Heterogeneity in Patient-Derived Tumor Xenografts

John W. Cassidy et al.

CANCER RESEARCH (2015)

Article Biochemistry & Molecular Biology

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

Marc van de Wetering et al.

Article Biochemistry & Molecular Biology

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj et al.

Review Biochemistry & Molecular Biology

A Review of Cell Adhesion Studies for Biomedical and Biological Applications

Amelia Ahmad Khalili et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Oncology

Patient-Derived Xenografts as a Model System for Radiation Research

Christopher D. Willey et al.

SEMINARS IN RADIATION ONCOLOGY (2015)

Article Multidisciplinary Sciences

Intestinal organoids for assessing nutrient transport, sensing and incretin secretion

Tamara Zietek et al.

SCIENTIFIC REPORTS (2015)

Article Materials Science, Biomaterials

Media additives to promote spheroid circularity and compactness in hanging drop platform

Brendan M. Leung et al.

BIOMATERIALS SCIENCE (2015)

Article Multidisciplinary Sciences

Imaging- and Flow Cytometry-based Analysis of Cell Position and the Cell Cycle in 3D Melanoma Spheroids

Kimberley A. Beaumont et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

Article Oncology

Spherical Cancer Models in Tumor Biology

Louis-Bastien Weiswald et al.

NEOPLASIA (2015)

Review Cell & Tissue Engineering

Additive manufacturing techniques for the production of tissue engineering constructs

Carlos Mota et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

Imaging Caspase-3 Activation as a Marker of Apoptosis-Targeted Treatment Response in Cancer

Delphine L. Chen et al.

MOLECULAR IMAGING AND BIOLOGY (2015)

Article Multidisciplinary Sciences

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells

Sarada Devi Ramachandran et al.

PLOS ONE (2015)

Article Oncology

FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

Isabelle Tancioni et al.

BREAST CANCER RESEARCH (2015)

Review Pharmacology & Pharmacy

3D cell culture systems modeling tumor growth determinants in cancer target discovery

Claudio R. Thoma et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Review Pharmacology & Pharmacy

Matrigel: From discovery and ECM mimicry to assays and models for cancer research

Gabriel Benton et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

Article Anatomy & Morphology

Analysis of cellular composition of co-culture spheroids

Natalie Dorst et al.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER (2014)

Review Engineering, Biomedical

3D Biofabrication Strategies for Tissue Engineering and Regenerative Medicine

Piyush Bajaj et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16 (2014)

Review Biochemical Research Methods

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

Rasheena Edmondson et al.

ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2014)

Article Biotechnology & Applied Microbiology

Optimization of Liquid Overlay Technique to Formulate Heterogenic 3D Co-Cultures Models

Elisabete C. Costa et al.

BIOTECHNOLOGY AND BIOENGINEERING (2014)

Article Biochemistry & Molecular Biology

Biophysical Characterization of Bladder Cancer Cells with Different Metastatic Potential

Haijiao Liu et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2014)

Review Medicine, Research & Experimental

Biological and medical applications of a brain-on-a-chip

David Pamies et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2014)

Article Medicine, Research & Experimental

LGR5 is required for the maintenance of spheroid-derived colon cancer stem cells

Xiang Chen et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2014)

Review Biotechnology & Applied Microbiology

Stem cell bioprocessing for regenerative medicine

Tiago G. Fernandes et al.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Comparison of the Hypoxia PET Tracer 18F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models

Satish K. Chitneni et al.

JOURNAL OF NUCLEAR MEDICINE (2014)

Article Cell & Tissue Engineering

Shear stress influences the pluripotency of murine embryonic stem cells in stirred suspension bioreactors

Tia Gareau et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2014)

Article Medicine, Research & Experimental

Hydrogel-Based 3D Model of Patient-Derived Prostate Xenograft Tumors Suitable for Drug Screening

Eliza L. S. Fong et al.

MOLECULAR PHARMACEUTICS (2014)

Article Biotechnology & Applied Microbiology

Microfluidic organs-on-chips

Sangeeta N. Bhatia et al.

NATURE BIOTECHNOLOGY (2014)

Review Biotechnology & Applied Microbiology

3D bioprinting of tissues and organs

Sean V. Murphy et al.

NATURE BIOTECHNOLOGY (2014)

Article Physics, Multidisciplinary

Dynamics of cell aggregates fusion: Experiments and simulations

Gilberto L. Thomas et al.

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS (2014)

Review Chemistry, Physical

Physics of cell adhesion: some lessons from cell-mimetic systems

Erich Sackmann et al.

SOFT MATTER (2014)

Review Cell & Tissue Engineering

Three-Dimensional Aggregates of Mesenchymal Stem Cells: Cellular Mechanisms, Biological Properties, and Applications

Sebastien Sart et al.

TISSUE ENGINEERING PART B-REVIEWS (2014)

Article Multidisciplinary Sciences

An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models

Jonathan P. Celli et al.

SCIENTIFIC REPORTS (2014)

Article Multidisciplinary Sciences

Sample Preparation Strategies for Mass Spectrometry Imaging of 3D Cell Culture Models

Dorothy R. Ahlf Wheatcraft et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2014)

Article Cell & Tissue Engineering

The fusion of tissue spheroids attached to pre-stretched electrospun polyurethane scaffolds

Vince Beachley et al.

JOURNAL OF TISSUE ENGINEERING (2014)

Article Biochemical Research Methods

The Resazurin Reduction Assay Can Distinguish Cytotoxic from Cytostatic Compounds in Spheroid Screening Assays

Angelika Walzl et al.

JOURNAL OF BIOMOLECULAR SCREENING (2014)

Review Chemistry, Multidisciplinary

25th Anniversary Article: Engineering Hydrogels for Biofabrication

Jos Malda et al.

ADVANCED MATERIALS (2013)

Review Biotechnology & Applied Microbiology

Bioreactor engineering of stem cell environments

Nina Tandon et al.

BIOTECHNOLOGY ADVANCES (2013)

Article Biotechnology & Applied Microbiology

Cryopreservation of pluripotent stem cell aggregates in defined protein-free formulation

Sebastien Sart et al.

BIOTECHNOLOGY PROGRESS (2013)

Review Pharmacology & Pharmacy

Three-dimensional cell culture: the missing link in drug discovery

Susan Breslin et al.

DRUG DISCOVERY TODAY (2013)

Review Biotechnology & Applied Microbiology

Bioprinting for stem cell research

Savas Tasoglu et al.

TRENDS IN BIOTECHNOLOGY (2013)

Review Biotechnology & Applied Microbiology

Spheroid culture as a tool for creating 3D complex tissues

Eelco Fennema et al.

TRENDS IN BIOTECHNOLOGY (2013)

Article Multidisciplinary Sciences

InVERT molding for scalable control of tissue microarchitecture

K. R. Stevens et al.

NATURE COMMUNICATIONS (2013)

Article Medicine, Research & Experimental

Why Is Organ Transplantation Clinically Important?

Josep M. Grinyo

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2013)

Article Developmental Biology

Differential adhesion in model systems

Ramsey A. Foty et al.

WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY (2013)

Review Oncology

Using space-based investigations to inform cancer research on Earth

Jeanne L. Becker et al.

NATURE REVIEWS CANCER (2013)

Review Chemistry, Multidisciplinary

Microfabricated Biomaterials for Engineering 3D Tissues

Pinar Zorlutuna et al.

ADVANCED MATERIALS (2012)

Article Cardiac & Cardiovascular Systems

Trends in the Indications and Survival in Pediatric Heart Transplants: A 24-year Single-Center Experience in 307 Patients

Rochus K. Voeller et al.

ANNALS OF THORACIC SURGERY (2012)

Review Biotechnology & Applied Microbiology

CHO cells in biotechnology for production of recombinant proteins: current state and further potential

Jee Yon Kim et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)

Article Engineering, Biomedical

Systematic engineering of 3D pluripotent stem cell niches to guide blood development

Kelly A. Purpura et al.

BIOMATERIALS (2012)

Review Biotechnology & Applied Microbiology

Drosophila melanogaster S2 cells for expression of heterologous genes: From gene cloning to bioprocess development

Angela M. Moraes et al.

BIOTECHNOLOGY ADVANCES (2012)

Article Anatomy & Morphology

Mass Transfer Limitations in Embryoid Bodies during Human Embryonic Stem Cell Differentiation

Allison P. Van Winkle et al.

CELLS TISSUES ORGANS (2012)

Article Cell Biology

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo

Hannah Schachtner et al.

EUROPEAN JOURNAL OF CELL BIOLOGY (2012)

Review Biotechnology & Applied Microbiology

Advances in the formation, use and understanding of multi-cellular spheroids

Toni-Marie Achilli et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2012)

Review Engineering, Biomedical

Engineering 3D cell-culture matrices: multiphoton processing technologies for biological and tissue engineering applications

Aleksandr Ovsianikov et al.

EXPERT REVIEW OF MEDICAL DEVICES (2012)

Article Chemistry, Multidisciplinary

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

Geeta Mehta et al.

JOURNAL OF CONTROLLED RELEASE (2012)

Article Multidisciplinary Sciences

Tissue deformation spatially modulates VEGF signaling and angiogenesis

Nicolas C. Rivron et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cell & Tissue Engineering

Direct Human Cartilage Repair Using Three-Dimensional Bioprinting Technology

Xiaofeng Cui et al.

TISSUE ENGINEERING PART A (2012)

Article Cell & Tissue Engineering

Biofabrication of Osteochondral Tissue Equivalents by Printing Topologically Defined, Cell-Laden Hydrogel Scaffolds

Natalja E. Fedorovich et al.

TISSUE ENGINEERING PART C-METHODS (2012)

Article Medicine, General & Internal

GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker

Katia C. Carvalho et al.

CLINICS (2011)

Article Cell Biology

The Metabolism of Human Mesenchymal Stem Cells During Proliferation and Differentiation

Girish Pattappa et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2011)

Review Chemistry, Medicinal

A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies

Nelita T. Elliott et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

Article Anatomy & Morphology

Multiphoton Fluorescence Lifetime Imaging of 3D-Stem Cell Spheroids During Differentiation

Karsten Koenig et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2011)

Article Biochemistry & Molecular Biology

Performance of a vortex flow bioreactor for cultivation of CHO-K1 cells on microcarriers

Patricia Aparecida Santiago et al.

PROCESS BIOCHEMISTRY (2011)

Article Engineering, Biomedical

Scalable robotic biofabrication of tissue spheroids

A. Nagy Mehesz et al.

BIOFABRICATION (2011)

Article Medicine, Research & Experimental

Current Standing and Future Prospects for the Technologies Proposed to Transform Toxicity Testing in the 21(st) Century

Erwin van Vliet

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2011)

Article Chemistry, Analytical

Microfluidic Western Blot

Wenying Pan et al.

ANALYTICAL CHEMISTRY (2010)

Article Biochemical Research Methods

In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract

Irina Arnaoutova et al.

NATURE PROTOCOLS (2010)

Article Multidisciplinary Sciences

Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties

Thomas J. Bartosh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Engineering, Biomedical

Tissue engineering by self-assembly and bio-printing of living cells

Karoly Jakab et al.

BIOFABRICATION (2010)

Article Medicine, General & Internal

Can Animal Models of Disease Reliably Inform Human Studies?

H. Bart van der Worp et al.

PLOS MEDICINE (2010)

Article Engineering, Biomedical

Organ printing: Tissue spheroids as building blocks

Vladimir Mironov et al.

BIOMATERIALS (2009)

Article Biotechnology & Applied Microbiology

Induction of Mammalian Cell Death by Simple Shear and Extensional Flows

Timm Tanzeglock et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Biotechnology & Applied Microbiology

Physiological Responses of CHO Cells to Repetitive Hydrodynamic Stress

Ruben Godoy-Silva et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Physics, Fluids & Plasmas

Comparing the growth kinetics of cell populations in two and three dimensions

M. Radszuweit et al.

PHYSICAL REVIEW E (2009)

Article Chemistry, Multidisciplinary

In vitro Toxicity Testing of Nanoparticles in 3D Cell Culture

Jungwoo Lee et al.

SMALL (2009)

Review Cell & Tissue Engineering

Vascularization Strategies for Tissue Engineering

Michael Lovett et al.

TISSUE ENGINEERING PART B-REVIEWS (2009)

Article Cell & Tissue Engineering

Towards an Extended Functional Hepatocyte In Vitro Culture

Joana P. Miranda et al.

TISSUE ENGINEERING PART C-METHODS (2009)

Review Biotechnology & Applied Microbiology

Design of bioreactors for mesenchymal stem cell tissue engineering

Pankaj Godara et al.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY (2008)

Article Biotechnology & Applied Microbiology

Miniaturization of an Anoikis assay using non-adhesive micromolded hydrogels

Adam P. Rago et al.

CYTOTECHNOLOGY (2008)

Article Biochemical Research Methods

Scaffold-free three-dimensional cell culture utilizing micromolded nonadhesive hydrogels

Anthony P. Napolitano et al.

BIOTECHNIQUES (2007)

Article Cell & Tissue Engineering

Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels

Anthony P. Napolitano et al.

TISSUE ENGINEERING (2007)

Review Biotechnology & Applied Microbiology

Methods for inducing embryoid body formation:: In vitro differentiation system of embryonic stem cells

Hiroshi Kurosawa

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2007)

Article Cell Biology

The cell as a material

Karen E. Kasza et al.

CURRENT OPINION IN CELL BIOLOGY (2007)

Review Engineering, Biomedical

Bioreactors for tissue mass culture: Design, characterization, and recent advances

Y Martin et al.

BIOMATERIALS (2005)

Review Oncology

Matrigel: Basement membrane matrix with biological activity

HK Kleinman et al.

SEMINARS IN CANCER BIOLOGY (2005)

Article Biochemistry & Molecular Biology

A single-cell-based model of tumor growth in vitro:: monolayers and spheroids

D Drasdo et al.

PHYSICAL BIOLOGY (2005)

Review Biotechnology & Applied Microbiology

Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals

M Butler

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2005)

Article Physics, Multidisciplinary

Rounding of aggregates of biological cells: Experiments and simulations

JCM Mombach et al.

PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS (2005)

Review Cell Biology

Podosomes: adhesion hot-spots of invasive cells

S Linder et al.

TRENDS IN CELL BIOLOGY (2003)

Article Physics, Condensed Matter

Hydrodynamics and cell motion during the rounding of two dimensional hydra cell aggregates

JP Rieu et al.

EUROPEAN PHYSICAL JOURNAL B (2002)

Article Cell Biology

Building 'validated' mouse models of human cancer

B Hann et al.

CURRENT OPINION IN CELL BIOLOGY (2001)

Article Oncology

Short exposure to millimolar concentrations of ethanol induces apoptotic cell death in multicellular HepG2 spheroids

F Castañeda et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2000)