4.6 Review

Interactions of HIV-1 Capsid with Host Factors and Their Implications for Developing Novel Therapeutics

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Cone-shaped HIV-1 capsids are transported through intact nuclear pores

Vojtech Zila et al.

Summary: The study reveals that the diameter of the nuclear pore complex in infected T cells is sufficient for the import of intact, cone-shaped capsids, with uncoating occurring by breaking the capsid open after nuclear import rather than disassembly into individual subunits. This visualization of a key step in HIV-1 replication enhances our understanding of the viral life cycle.
Review Pharmacology & Pharmacy

Combination therapies currently under investigation in phase I and phase II clinical trials for HIV-1

Hanh Thi Pham et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2020)

Article Multidisciplinary Sciences

HIV-1 uncoats in the nucleus near sites of integration

Ryan C. Burdick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid

Alvin Yu et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Multidisciplinary

Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders

Derrick Lau et al.

LANGMUIR (2020)

Review Biochemistry & Molecular Biology

Recent Advances in HIV-1 Gag Inhibitor Design and Development

Alexej Dick et al.

MOLECULES (2020)

Review Microbiology

Network-Based Analysis of OMICs Data to Understand the HIV-Host Interaction

Sergey Ivanov et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Multidisciplinary Sciences

Clinical targeting of HIV capsid protein with a long-acting small molecule

John O. Link et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

Tao Ni et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Review Virology

HIV-1 Maturation: Lessons Learned from Inhibitors

Alex B. Kleinpeter et al.

VIRUSES-BASEL (2020)

Article Cell Biology

Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating

Anastasia Selyutina et al.

CELL REPORTS (2020)

Article Biochemistry & Molecular Biology

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

Chaoyi Xu et al.

PLOS BIOLOGY (2020)

Review Microbiology

From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1

Pavitra Ramdas et al.

FRONTIERS IN MICROBIOLOGY (2020)

Review Biochemistry & Molecular Biology

A snapshot of HIV-1 capsid-host interactions

Joshua Temple et al.

CURRENT RESEARCH IN STRUCTURAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Structural and mechanistic bases for a potent HIV-1 capsid inhibitor

Stephanie M. Bester et al.

SCIENCE (2020)

Review Biochemistry & Molecular Biology

The Structure of the Nuclear Pore Complex (An Update)

Daniel H. Lin et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Article Biophysics

Structure and Assembly of the Nuclear Pore Complex

Bernhard Hampoelz et al.

Annual Review of Biophysics (2019)

Article Biochemistry & Molecular Biology

MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid

Sarah Sierra Smaga et al.

STRUCTURE (2019)

Review Physiology

Experimental Analysis of Viral-Host Interactions

Joseph Gillen et al.

FRONTIERS IN PHYSIOLOGY (2019)

Review Virology

Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle

Mariia Novikova et al.

VIROLOGICA SINICA (2019)

Review Microbiology

Restriction of HIV-1 and other retroviruses by TRIM5

Barbie K. Ganser-Pornillos et al.

NATURE REVIEWS MICROBIOLOGY (2019)

Review Biochemistry & Molecular Biology

Molecular Mechanism of HIV-1 Entry

Bing Chen

TRENDS IN MICROBIOLOGY (2019)

Article Microbiology

GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds

Kamal Singh et al.

FRONTIERS IN MICROBIOLOGY (2019)

Article Microbiology

Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms

Brady J. Summers et al.

CELL HOST & MICROBE (2019)

Article Biochemistry & Molecular Biology

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

Stephen R. Yant et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids

Katarzyna A. Skorupka et al.

SCIENCE ADVANCES (2019)

Review Medicine, Research & Experimental

HIV Capsid Inhibitors Beyond PF74

Carole McArthur et al.

DISEASES (2019)

Review Biochemistry & Molecular Biology

Review HIV Vaccination: A Roadmap among Advancements and Concerns

Maria Trovato et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Immunology

Inhibitors of the HIV-1 capsid, a target of opportunity

Stephanie K. Carnes et al.

CURRENT OPINION IN HIV AND AIDS (2018)

Article Microbiology

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

Vasudevan Achuthan et al.

CELL HOST & MICROBE (2018)

Article Virology

HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus

Stephanie K. Carnes et al.

JOURNAL OF VIROLOGY (2018)

Article Multidisciplinary Sciences

Inositol phosphates are assembly co-factors for HIV-1

Robert A. Dick et al.

NATURE (2018)

Article Biotechnology & Applied Microbiology

Efficient proximity labeling in living cells and organisms with TurboID

Tess C. Branon et al.

NATURE BIOTECHNOLOGY (2018)

Article Virology

Viruses.STRING: A Virus-Host Protein-Protein Interaction Database

Helen Victoria Cook et al.

VIRUSES-BASEL (2018)

Review Biochemistry & Molecular Biology

Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology

Francis J. O'Reilly et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Virology

IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating

Robert A. Dick et al.

VIRUSES-BASEL (2018)

Review Immunology

Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1

Marta Colomer-Lluch et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Biology

Atomic force microscopy reveals structural variability amongst nuclear pore complexes

George J. Stanley et al.

LIFE SCIENCE ALLIANCE (2018)

Article Genetics & Heredity

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

Ryan J. Park et al.

NATURE GENETICS (2017)

Review Cell Biology

The nuclear pore complex: understanding its function through structural insight

Martin Beck et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Virology

Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly

Sanela Rankovic et al.

JOURNAL OF VIROLOGY (2017)

Article Multidisciplinary Sciences

Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection

Adarsh Dharan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Early cytoplasmic uncoating is associated with infectivity of HIV-1

Joao I. Mamede et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

Capsid-Dependent Host Factors in HIV-1 Infection

Masahiro Yamashita et al.

TRENDS IN MICROBIOLOGY (2017)

Review Biochemistry & Molecular Biology

Structure Determination of the Nuclear Pore Complex with Three-Dimensional Cryo electron Microscopy

Alexander von Appen et al.

JOURNAL OF MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

David A. Jacques et al.

NATURE (2016)

Article Multidisciplinary Sciences

A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Gregory A. Sowd et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Biochemical Research Methods

Meet the neighbors: Mapping local protein interactomes by proximity-dependent labeling with BioID

Renata Varnaite et al.

PROTEOMICS (2016)

Article Multidisciplinary Sciences

The structure and flexibility of conical HIV-1 capsids determined within intact virions

Simone Mattei et al.

SCIENCE (2016)

Article Mathematical & Computational Biology

HPIDB 2.0: a curated database for host-pathogen interactions

Mais G. Ammari et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2016)

Review Immunology

Innate immunity against HIV-1 infection

Marcus Altfeld et al.

NATURE IMMUNOLOGY (2015)

Review Microbiology

HIV-1 capsid: the multifaceted key player in HIV-1 infection

Edward M. Campbell et al.

NATURE REVIEWS MICROBIOLOGY (2015)

Article Multidisciplinary Sciences

HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus

Viacheslav Malikov et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Microtubule-associated Proteins 1 (MAP1) Promote Human Immunodeficiency Virus Type I (HIV-1) Intracytoplasmic Routing to the Nucleus

Juliette Fernandez et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemical Research Methods

Directed evolution of APEX2 for electron microscopy and proximity labeling

Stephanie S. Lam et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

VirusMentha: a new resource for virus-host protein interactions

Alberto Calderone et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

VirHostNet 2.0: surfing on the web of virus/host molecular interactions data

Thibaut Guirimand et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

HIV-1, human interaction database: current status and new features

Danso Ako-Adjei et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Immunology

Type I interferons in infectious disease

Finlay McNab et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

Akash Bhattacharya et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Probing nuclear pore complex architecture with proximity-dependent biotinylation

Dae In Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Virology

MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1

Thomas Fricke et al.

RETROVIROLOGY (2014)

Article Virology

Proteome analysis of the HIV-1 Gag interactome

Christine E. Engeland et al.

VIROLOGY (2014)

Article Microbiology

A Cyclophilin Homology Domain-Independent Role for Nup358 in HIV-1 Infection

Anne M. Meehan et al.

PLOS PATHOGENS (2014)

Article Virology

The Impact of Mass Spectrometry-Based Proteomics on Fundamental Discoveries in Virology

Todd M. Greco et al.

ANNUAL REVIEW OF VIROLOGY, VOL 1 (2014)

Article Biochemistry & Molecular Biology

Structural and Functional Analysis of the C-Terminal Domain of Nup358/RanBP2

Daniel H. Lin et al.

JOURNAL OF MOLECULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

HIV-1 evades innate immune recognition through specific cofactor recruitment

Jane Rasaiyaah et al.

NATURE (2013)

Article Multidisciplinary Sciences

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

Caroline Goujon et al.

NATURE (2013)

Article Multidisciplinary Sciences

MX2 is an interferon-induced inhibitor of HIV-1 infection

Melissa Kane et al.

NATURE (2013)

Review Cell Biology

HIV trafficking in host cells: motors wanted!

Raphael Gaudin et al.

TRENDS IN CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Global landscape of HIV-human protein complexes

Stefanie Jaeger et al.

NATURE (2012)

Article Biotechnology & Applied Microbiology

Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

Jeffrey D. Martell et al.

NATURE BIOTECHNOLOGY (2012)

Meeting Abstract Biochemical Research Methods

PHISTO: Pathogen-Host Interaction Search Tool

Saliha Durmus Tekir et al.

NEW BIOTECHNOLOGY (2012)

Article Multidisciplinary Sciences

Human Nucleoporins Promote HIV-1 Docking at the Nuclear Pore, Nuclear Import and Integration

Francesca Di Nunzio et al.

PLOS ONE (2012)

Article Medicine, Research & Experimental

HIV-1 Pathogenesis: The Virus

Ronald Swanstrom et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Medicine, Research & Experimental

HIV-1 Assembly, Budding, and Maturation

Wesley I. Sundquist et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Medicine, Research & Experimental

HIV-1 Antiretroviral Drug Therapy

Eric J. Arts et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Medicine, Research & Experimental

HIV Restriction Factors and Mechanisms of Evasion

Michael H. Malim et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Virology

TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling

Markus G. Gruetter et al.

CURRENT OPINION IN VIROLOGY (2012)

Article Microbiology

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

Amanda J. Price et al.

PLOS PATHOGENS (2012)

Article Cell Biology

HIV-1 remodels the nuclear pore complex

Anne Monette et al.

JOURNAL OF CELL BIOLOGY (2011)

Article Biochemical Research Methods

Purification and characterization of HIV-human protein complexes

Stefanie Jaeger et al.

METHODS (2011)

Review Virology

Host factors mediating HIV-1 replication

Brian M. Friedrich et al.

VIRUS RESEARCH (2011)

Review Pharmacology & Pharmacy

The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic

Samuel Broder

ANTIVIRAL RESEARCH (2010)

Article Microbiology

Flexible Use of Nuclear Import Pathways by HIV-1

KyeongEun Lee et al.

CELL HOST & MICROBE (2010)

Review Virology

Revisiting HIV-1 uncoating

Nathalie Arhel

RETROVIROLOGY (2010)

Article Microbiology

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

Wade S. Blair et al.

PLOS PATHOGENS (2010)

Article Biochemistry & Molecular Biology

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

Owen Pornillos et al.

Article Biochemistry & Molecular Biology

A Genome-wide Short Hairpin RNA Screening of Jurkat T-cells for Human Proteins Contributing to Productive HIV-1 Replication

Man Lung Yeung et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Microbiology

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

Frederic D. Bushman et al.

PLOS PATHOGENS (2009)

Article Biochemistry & Molecular Biology

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication

Renate Konig et al.

Article Microbiology

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

Honglin Zhou et al.

CELL HOST & MICROBE (2008)

Review Biochemical Research Methods

High confidence determination of specific protein-protein interactions using quantitative mass spectrometry

Michiel Vermeulen et al.

CURRENT OPINION IN BIOTECHNOLOGY (2008)

Review Biochemistry & Molecular Biology

The structural biology of HIV assembly

Barbie K. Ganser-Pornillos et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2008)

Article Multidisciplinary Sciences

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5α restriction factor

M Stremlau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1

G Fätkenheuer et al.

NATURE MEDICINE (2005)

Review Biochemistry & Molecular Biology

HIV-1 pathogenesis

M Stevenson

NATURE MEDICINE (2003)