Journal
ENVIRONMENTAL HEALTH
Volume 15, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12940-016-0180-6
Keywords
Aneuploidy; Carcinogens; Reproductive toxicants; Endocrine disruptors; Chromosomes; Early diagnose; Bioassays; Risk assessment; mFISH; Laser scanning microscopy
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Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.
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