Recent epidemiologic and clinical Toxoplasma gondii infections in wild canids and other carnivores: 2009-2020

Toxoplasma gondii infections are common in humans and animals worldwide. The present review summarizes worldwide information on the prevalence of clinical and subclinical infections, epidemiology, diagnosis, and genetic diversity of T. gondii in wild canids and other carnivores for the past decade. Seroprevalence estimates of T. gondii worldwide were tabulated for each host. Semprevalence in wild foxes was very high compared with farmed Arctic foxes. Economic and public health aspects of some of the carnivore species raised for fur and meat (raccoon dogs, mink) are discussed. Diagnostic efficacies of different serological methods and PCR methods are discussed. Clinical toxoplasmosis was observed mainly in carnivores concurrently infected with immunosuppressive Canine Distemper Virus infection. Abortion and blindness were noted in mink. Genetic diversity of isolates using DNA derived from 162 (89 viable T. gondii isolates and 73 DNA extracted from tissues) of wild carnivores from several countries is discussed. However, 69 of the 162 T. gondii isolates were strains from USA and these were genetically diverse with predominance of ToxoDB genotypes #4 and #5 (haplogroup 12). Only limited information is available concerning genotyping of T. gondii isolates from other countries; none of the 93 T. gondii isolates from other countries (Brazil, China, France, Grenada) were haplogroup 12.

Automated summary

This review summarizes global information on Toxoplasma gondii infections, covering clinical and subclinical infections, epidemiology, diagnosis, and genetic diversity in wild canids and other carnivores. The study found high seroprevalence in wild foxes compared to farmed Arctic foxes, discussed economic and public health issues related to some carnivore species, and evaluated diagnostic methods and genetic diversity. It highlighted clinical toxoplasmosis in carnivores with concurrent Canine Distemper Virus infection, as well as genetic diversity of isolates notably in the USA. Limited information was available on genotyping isolates from other countries such as Brazil, China, France, and Grenada.