Journal
VETERINARNI MEDICINA
Volume 66, Issue 5, Pages 225-232Publisher
CZECH ACADEMY AGRICULTURAL SCIENCES
DOI: 10.17221/115/2020-VETMED
Keywords
cytology; histopathology; immunohistochemistry; programmed cell death protein 1; Reed-Sternberg cell
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Funding
- Konkuk University Researcher Fund
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A 3-year-old castrated male ferret suspected of lymphoma showed invasive neoplastic cells in mesenteric lymph nodes, liver, and spleen. Immunohistochemistry revealed similarities to human Hodgkin's lymphoma, with significant PD-1 expression suggesting a potential novel diagnostic and prognostic factor for ferrets.
A 3-year-old castrated male ferret was suspected to have lymphoma based on a markedly enlarged mesenteric lymph node. Hodgkin's-like lymphoma (HLL) was suspected because numerous Reed-Sternberg-like cells were observed in the fine-needle aspiration biopsy of the mesenteric lymph node. In the post-mortem histopathology, neoplastic cells were invasively proliferated not only in the mesenteric lymph nodes, but also in the liver and spleen. Immunohistochemically, most neoplastic cells were positive for vimentin and BLA-36, weakly positive for CD20, and negative for Pax5, CD79a, CD3, CD45, and Iba-1, demonstrating similarity to human Hodgkin's lymphoma ( HL). In addition, a prominent programmed cell death protein 1 (PD-1) expression was observed at the sites showing malignant tumour proliferation. HLL in non-human beings can be morphologically and immunophenotypically similar to human HL, but the prognosis and clinical outcome may differ. This is the first study analysing the PD-1 expression in a ferret, suggesting that PD-1 can be a novel diagnostic and prognostic factor in a similar manner to humans.
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