Journal
ULTRASONICS
Volume 110, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ultras.2020.106244
Keywords
BBB; FUS; Phantom; Ultrasound
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A high intensity focused ultrasound phantom model was developed for experiments on Blood Brain Barrier disruption. The model successfully simulated BBB disruption during ultrasound application and has the potential to be a cost-effective alternative to animal experiments.
In this paper a high intensity focused ultrasound (FUS) phantom model was developed, in order to be used in experiments for Blood Brain Barrier (BBB) disruption. The target was to create a phantom model that represents the disruption of the BBB during ultrasound application. An appropriate experimental setup was created bearing a single element transducer with diameter 50 mm and geometric focus 100 mm operating at 0.5 MHz. It included a set of tubes and a connector with multiple 0.4 mm openings, through which a suitable liquid is being circulated with a pump. The lesions were sealed with a thin homogenous layer of wax, preventing a liquid leakage. The system was tested successfully with FUS and a liquid leakage was achieved after FUS application. This set up is the first phantom model that has the potential to be utilized as a cost-effective solution for performing experiments for BBB disruption, without the need of using animal models.
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