Journal
TRENDS IN NEUROSCIENCES
Volume 44, Issue 2, Pages 110-121Publisher
CELL PRESS
DOI: 10.1016/j.tins.2020.10.012
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Funding
- F.R.S.-F.N.R.S.(Synet) [EOS0019118F-RG36]
- Fonds Leon Fredericq
- Fondation Medicale Reine Elisabeth
- Fondation Simoneet Pierre Clerdent
- Belgian Science Policy (IAP-VII network) [P7/20]
- ERANET Neuron STEM-MCD
- Neuro Talk
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During brain development, changes in brain biomechanical properties are converted into intracellular signals through mechanotransduction to control neuronal differentiation. Existing tools and emerging technologies can be used to assess and manipulate the physical properties of neurons and their environment.
During brain development, progenitors generate successive waves of neurons that populate distinct cerebral regions, where they settle and differentiate within layers or nuclei. While migrating and differentiating, neurons are subjected to mechanical forces arising from the extracellular matrix, and their interaction with neighboring cells. Changes in brain biomechanical properties, during its formation or aging, are converted in neural cells by mechanotransduction into intracellular signals that control key neurobiological processes. Here, we summarize recent findings that support the contribution of mechanobiology to neurodevelopment, with focus on the cerebral cortex. Also discussed are the existing toolbox and emerging technologies made available to assess and manipulate the physical properties of neurons and their environment.
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