Related references
Note: Only part of the references are listed.Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Maria Grazia Vizioli et al.
GENES & DEVELOPMENT (2020)
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress?induced senescence
Xiaojuan Han et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2020)
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP
Vladislav Pokatayev et al.
NATURE IMMUNOLOGY (2020)
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis
Chi G. Weindel et al.
ELIFE (2020)
Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke
Qian Li et al.
EMBO MOLECULAR MEDICINE (2020)
Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation
Junzhong Lai et al.
FRONTIERS IN PHARMACOLOGY (2020)
Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration
Abhishek Jauhari et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases
Guo Chen et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
COVID-19 as a STING disorder with delayed over-secretion of interferon-beta
Jean-Marie Berthelot et al.
EBIOMEDICINE (2020)
Regulation and Consequences of cGAS Activation by Self-DNA
Christian Zierhut et al.
TRENDS IN CELL BIOLOGY (2020)
Cytosolic DNA Sensors and CNS Responses to Viral Pathogens
Austin M. Jeffries et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)
Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?
Jean-Marie Berthelot et al.
EMERGING MICROBES & INFECTIONS (2020)
STING palmitoylation as a therapeutic target
Anne Louise Hansen et al.
CELLULAR & MOLECULAR IMMUNOLOGY (2019)
Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression
Arshed Nazmi et al.
GLIA (2019)
Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3
Xiaohan Ning et al.
MOLECULAR CELL (2019)
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Xiang Gui et al.
NATURE (2019)
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Evandro F. Fang et al.
NATURE NEUROSCIENCE (2019)
Discovery of GSK8612, a Highly Selective and Potent TBK1 Inhibitor
Douglas W. Thomson et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
SLC19A1 Is an Importer of the Immunotransmitter cGAMP
Christopher Ritchie et al.
MOLECULAR CELL (2019)
Accumulation of Cytoplasmic DNA Due to ATM Deficiency Activates the Microglial Viral Response System with Neurotoxic Consequences
Xuan Song et al.
JOURNAL OF NEUROSCIENCE (2019)
CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset
Jong-Min Lee et al.
CELL (2019)
Cutting Edge: USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA-Mediated Signaling
Yunyun Guo et al.
JOURNAL OF IMMUNOLOGY (2019)
SLC19A1 transports immunoreactive cyclic dinucleotides
Rutger D. Luteijn et al.
NATURE (2019)
LRRK2 regulation of immune-pathways and inflammatory disease
Rebecca L. Wallings et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2019)
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING
Tony Siu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease
Jeonghan Kim et al.
SCIENCE (2019)
Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
Yuk Yuen Lan et al.
AGING CELL (2019)
SnapShot: Mitochondrial Nucleoid
Nina A. Bonekamp et al.
CELL (2018)
Aging, inflammation and the environment
Arsun Bektas et al.
EXPERIMENTAL GERONTOLOGY (2018)
Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-β levels
Modi Wang et al.
FUTURE MEDICINAL CHEMISTRY (2018)
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
Kate McArthur et al.
SCIENCE (2018)
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells
Akiko Takahashi et al.
NATURE COMMUNICATIONS (2018)
A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin
Ray Kreienkamp et al.
CELL REPORTS (2018)
Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKK epsilon and Reveal Mechanisms for Selective Inhibition
Tyler S. Beyett et al.
MOLECULAR PHARMACOLOGY (2018)
Parkin and PINK1 mitigate STING-induced inflammation
Danielle A. Sliter et al.
NATURE (2018)
Targeting STING with covalent small-molecule inhibitors
Simone M. Haag et al.
NATURE (2018)
SAMHD1 acts at stalled replication forks to prevent interferon induction
Flavie Coquel et al.
NATURE (2018)
Inflammaging: a new immune-metabolic viewpoint for age-related diseases
Claudio Franceschi et al.
NATURE REVIEWS ENDOCRINOLOGY (2018)
Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
Anne Louise Hansen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
Senlin Li et al.
CELL REPORTS (2018)
Inflammatory Response in the CNS: Friend or Foe?
Marta Sochocka et al.
MOLECULAR NEUROBIOLOGY (2017)
cGAS surveillance of micronuclei links genome instability to innate immunity
Karen J. Mackenzie et al.
NATURE (2017)
Mitotic progression following DNA damage enables pattern recognition within micronuclei
Shane M. Harding et al.
NATURE (2017)
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders
Liudmila Andreeva et al.
NATURE (2017)
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Selene Gluck et al.
NATURE CELL BIOLOGY (2017)
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation
Vidhu Mathur et al.
NEURON (2017)
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
Jessica Vincent et al.
NATURE COMMUNICATIONS (2017)
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Justin Hall et al.
PLOS ONE (2017)
Immunomodulation in multiple sclerosis: promises and pitfalls
Calliope A. Dendrou et al.
CURRENT OPINION IN IMMUNOLOGY (2017)
RNase H2 catalytic core Aicardi-Goutieres syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice
Vladislav Pokatayev et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2016)
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Aleksandra Deczkowska et al.
TRENDS IN IMMUNOLOGY (2016)
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS
Line S. Reinert et al.
NATURE COMMUNICATIONS (2016)
Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System
Chin Wai Hui et al.
PLOS ONE (2016)
An RNA-Based Fluorescent Biosensor for High-Throughput Analysis of the cGAS-cGAMP-STING Pathway
Debojit Bose et al.
CELL CHEMICAL BIOLOGY (2016)
Characterization of Human Disease Phenotypes Associated with Mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1
Yanick J. Crow et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2015)
The roles of CRISPR-Cas systems in adaptive immunity and beyond
Rodolphe Barrangou
CURRENT OPINION IN IMMUNOLOGY (2015)
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
Anetta Hartlova et al.
IMMUNITY (2015)
Cutting Edge: Antimalarial Drugs Inhibit IFN-β Production through Blockade of Cyclic GMP-AMP Synthase-DNA Interaction
Jie An et al.
JOURNAL OF IMMUNOLOGY (2015)
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutieres Syndrome
Elizabeth E. Gray et al.
JOURNAL OF IMMUNOLOGY (2015)
Interferon-α Induces Neurotoxicity Through Activation of the Type I Receptor and the GluN2A Subunit of the NMDA Receptor
Cari F. Kessing et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2015)
Mitochondrial DNA stress primes the antiviral innate immune response
A. Phillip West et al.
NATURE (2015)
Huntington disease
Gillian P. Bates et al.
NATURE REVIEWS DISEASE PRIMERS (2015)
Individual Cytokines Modulate the Neurological Symptoms of ATM Deficiency in a Region Specific Manner
Chin Wai Hui et al.
ENEURO (2015)
The Genetic Modifiers of Motor Onset Age (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease
Kevin Correia et al.
JOURNAL OF HUNTINGTONS DISEASE (2015)
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J. White et al.
CELL (2014)
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Anthony Rongvaux et al.
CELL (2014)
Interferons in the Central Nervous System: A Few Instruments Play Many Tunes
Trevor Owens et al.
GLIA (2014)
Selective TBK1/IKKi dual inhibitors with anticancer potency
Jijia Li et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
The role of senescent cells in ageing
Jan M. van Deursen
NATURE (2014)
Aging-induced type I interferon response at the choroid plexus negatively affects brain function
Kuti Baruch et al.
SCIENCE (2014)
Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation
Huu B. Ngo et al.
NATURE COMMUNICATIONS (2014)
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
Xu Zhang et al.
CELL REPORTS (2014)
Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy
Yuk Yuen Lan et al.
CELL REPORTS (2014)
IFN-γ-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair
Gilad Kunis et al.
BRAIN (2013)
Type I interferon in neurological disease-The devil from within
Markus J. Hofer et al.
CYTOKINE & GROWTH FACTOR REVIEWS (2013)
Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
Nadine Gehrke et al.
IMMUNITY (2013)
The interferons and their receptors-distribution and regulation
Nicole A. de Weerd et al.
IMMUNOLOGY AND CELL BIOLOGY (2012)
Progressive multiple sclerosis: The treatment gap
Courtney Humphries
NATURE (2012)
Progressive multiple sclerosis: pathology and pathogenesis
Hans Lassmann et al.
NATURE REVIEWS NEUROLOGY (2012)
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
Guijun Shang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain
Dyna I. Shirasaki et al.
NEURON (2012)
T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
Robert C. Axtell et al.
NATURE MEDICINE (2010)
Interferon-α Causes Neuronal Dysfunction in Encephalitis
Andrew R. Sas et al.
JOURNAL OF NEUROSCIENCE (2009)
Viral Subversion of Apoptotic Enzymes: Escape from Death Row
Sonja M. Best
ANNUAL REVIEW OF MICROBIOLOGY (2008)
The aging brain
Bruce A. Yankner et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)
Type 1 interferons cool the inflamed brain
Robert C. Axtell et al.
IMMUNITY (2008)
Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
Marco Prinz et al.
IMMUNITY (2008)
HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation
Atsushi Okumura et al.
VIROLOGY (2008)
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
Yun-Gui Yang et al.
CELL (2007)
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection
Yanick J. Crow et al.
NATURE GENETICS (2006)
Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
Yanick J. Crow et al.
NATURE GENETICS (2006)
Cellular senescence in aging primates
U Herbig et al.
SCIENCE (2006)
Complex modulation of cell type-specific signaling in response to type I Interferons
Anette H. H. van Boxel-Dezaire et al.
IMMUNITY (2006)
The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus
M Ida-Hosonuma et al.
JOURNAL OF VIROLOGY (2005)
PINK1 mutations are associated with sporadic early-onset parkinsonism
EM Valente et al.
ANNALS OF NEUROLOGY (2004)
Share Paper
