Journal
TRENDS IN MOLECULAR MEDICINE
Volume 27, Issue 3, Pages 248-262Publisher
CELL PRESS
DOI: 10.1016/j.molmed.2020.10.002
Keywords
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Funding
- European Regional Development Fund (ERDF) through the Operational Program for Competitiveness Factors (COMPETE) [PAC 'NETDIAMOND' POCI-01-0145-FEDER-016385, HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323, POCI-01-0145-FEDER-007440, CENTRO-01-0145FEDER-032179, CENTRO-01-0145-FEDER-032414, POCI-01-0145-FEDER-022122, FCTUID/NEU/04539/2013, UID/NEU/04539/2019, UIDB/04539/2020, UIDP/04539/2020]
- Fundacao para a Ciencia e a Tecnologia (FCT) [PD/BD/106043/2015]
- Duke-NUS Signature Research Programme - Ministry of Health
- Singapore Ministry of Health's National Medical Research Council under its Clinician Scientist-Senior Investigator scheme [NMRC/CSA-SI/0011/2017]
- Centre Grant and Collaborative Centre Grant scheme [NMRC/CGAug16C006]
- COST (European Cooperation in Science and Technology) [CA16225]
- Horizon2020 ERC-2016-CoG EVICARE [725229]
- PPP Allowance Research Project from Top Sector Life Sciences & Health to Hartstichting [2018B014]
- Fund for Scientific Research Flanders, Belgium [G.0527.18N, G.0407.20N]
- Special Research Fund of Ghent University
- European Research Council (ERC) [725229] Funding Source: European Research Council (ERC)
- Fundação para a Ciência e a Tecnologia [PD/BD/106043/2015] Funding Source: FCT
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Cell-to-cell communication plays a crucial role in maintaining tissue homeostasis, and disruptions in this communication have been implicated in harmful consequences of heart ischemia and reperfusion, such as arrhythmias and heart failure. Targeting intercellular communication mechanisms may offer potential therapeutic strategies to prevent or repair these consequences and restore myocardial function.
The maintenance of tissue, organ, and organism homeostasis relies on an intricate network of players and mechanisms that assist in the different forms of cell-cell communication. Myocardial infarction, following heart ischemia and reperfusion, is associated with profound changes in key processes of intercellular communication, involving gap junctions, extracellular vesicles, and tunneling nanotubes, some of which have been implicated in communication defects associated with cardiac injury, namely arrhythmogenesis and progression into heart failure. Therefore, intercellular communication players have emerged as attractive powerful therapeutic targets aimed at preserving a fine-tuned crosstalk between the different cardiac cells in order to prevent or repair some of harmful consequences of heart ischemia and reperfusion, re-establishing myocardial function.
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