4.6 Editorial Material

Sensory Nerves Regulate Transcriptional Dynamics of Lymph Node Cells

Journal

TRENDS IN IMMUNOLOGY
Volume 42, Issue 3, Pages 180-182

Publisher

CELL PRESS
DOI: 10.1016/j.it.2021.01.008

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Funding

  1. NIH [R37AI049653, R01DK119147, DP1DK126190]
  2. Synergy Award from the Rainin Foundation
  3. Principles in Pulmonary Research training grant [T32 HL007317-41]
  4. Lawrence C. Pakula, MD IBD Education & Innovation Fund [FA-2020-01-IBD-1]

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The nervous system plays crucial roles in maintaining tissue homeostasis and regulating inflammatory responses. Recent studies have shown that lymph nodes are innervated by unique peptidergic nociceptors, signaling to various cell types within the lymph nodes.
The nervous system plays important roles in homeostasis and inflammatory responses in tissues. However, the regulation of lymph nodes (LN) by nerves remains largely unknown. Huang et al. demonstrate that LNs are innervated by unique peptidergic nociceptors that signal to various endothelial, stromal, and immune cell types in LNs.

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